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Volume 128, Issue 1
1 July 1968
Journal of Experimental Medicine Cover Image for Volume 128, Issue 1
Article| July 01 1968

CELLULAR IMMUNITY IN VACCINIA INFECTION OF MICE : ANTI-THYMOCYTE SERUM EFFECTS ON PRIMARY AND SECONDARY RESPONSIVENESS

Martin S. Hirsch,
Martin S. Hirsch
From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333
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André J. Nahmias,
André J. Nahmias
From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333
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Frederick A. Murphy,
Frederick A. Murphy
From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333
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Joel H. Kramer
Joel H. Kramer
From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333
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Author and Article Information
Martin S. Hirsch
From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333
André J. Nahmias
From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333
Frederick A. Murphy
From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333
Joel H. Kramer
From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333
Received: March 28 1968
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1968 by The Rockefeller University Press
1968
J Exp Med (1968) 128 (1): 121–132.
https://doi.org/10.1084/jem.128.1.121
Article history
Received:
March 28 1968

Rabbit anti-mouse thymocyte serum suppressed host cell-mediated responsiveness to intravenously administered vaccinia virus, thereby augmenting the morbidity and mortality of this infection. It did not affect either humoral antibody or interferon production in response to vaccinia virus. No effects were noted on primary or secondary immunity to intracerebral virus inoculation.

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Copyright © 1968 by The Rockefeller University Press
1968
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