The existence of a virus-induced, virus-specific transplantation, antigen in adenovirus 12-induced CBA mouse tumors was demonstrated. The antigen is virus-specific, but not related to structural virion or T antigens. It is a weak antigen, and required immunization with whole, infectious adenovirus 12 to produce considerable immunity. Comparable immunity could not be achieved with homologous cellular or subcellular materials, but some indication of enhancement was produced with low tumor dose. Immunization required at least 2 wk and was mediated by immune lymphoid cells. Serum of immunized animals showed no demonstrable cytotoxicity or enhancement. Animals immunized with virus and Freund's adjuvant showed diminished transplantation immunity, although these animals were actively immunized against adenovirus type 12 structural virion antigens.
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1 June 1967
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June 01 1967
ON THE NATURE OF TRANSPLANTATION IMMUNITY IN THE ADENOVIRUS TUMOR SYSTEM
Leonard D. Berman
Leonard D. Berman
From the National Institute for Medical Research, Mill Hill, London, England
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Leonard D. Berman
From the National Institute for Medical Research, Mill Hill, London, England
Received:
January 19 1967
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1967 by The Rockefeller University Press
1967
J Exp Med (1967) 125 (6): 983–1000.
Article history
Received:
January 19 1967
Citation
Leonard D. Berman; ON THE NATURE OF TRANSPLANTATION IMMUNITY IN THE ADENOVIRUS TUMOR SYSTEM . J Exp Med 1 June 1967; 125 (6): 983–1000. doi: https://doi.org/10.1084/jem.125.6.983
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