THE ORIGIN OF THE CELLS IN THE EFFERENT LYMPH FROM A SINGLE LYMPH NODE

Hall , J. G.; Morris , Bede

doi:10.1084/jem.121.6.901

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Article| June 01 1965

THE ORIGIN OF THE CELLS IN THE EFFERENT LYMPH FROM A SINGLE LYMPH NODE

J. G. Hall,

J. G. Hall

From the Department of Experimental Pathology, John Curtin School of Medical Research, The Australian National University, Canberra, Australia

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Bede Morris

From the Department of Experimental Pathology, John Curtin School of Medical Research, The Australian National University, Canberra, Australia

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Author and Article Information

J. G. Hall

From the Department of Experimental Pathology, John Curtin School of Medical Research, The Australian National University, Canberra, Australia

Bede Morris

From the Department of Experimental Pathology, John Curtin School of Medical Research, The Australian National University, Canberra, Australia

Received: January 31 1965

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1965

J Exp Med (1965) 121 (6): 901–910.

https://doi.org/10.1084/jem.121.6.901

The popliteal nodes of sheep were perfused continuously for over 100 hours with a solution containing ³H-thymidine. The labelling pattern of the lymphocytes in the efferent lymph from the perfused nodes showed that under normal conditions not more than 4 per cent of these lymphocytes were actually produced in the node. The transitional cells, large lymphocytes and cells of the plasma cell series which appeared in the lymph following antigenic stimulation of the node were all produced in the node.

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