THE IN VITRO ACTION OF HYDROCORTISONE ON LEUCOCYTE MIGRATION

Ketchel , Melvin M.; Favour , Cutting B.; Sturgis , Somers H.; With the Technical Assistance of Aurelia C. Koros and Frances Mao

doi:10.1084/jem.107.2.211

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Article| February 01 1958

THE IN VITRO ACTION OF HYDROCORTISONE ON LEUCOCYTE MIGRATION

Melvin M. Ketchel,

Melvin M. Ketchel

From the Departments of Surgery, Harvard Medical School and the Peter Bent Brigham Hospital, Boston

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Cutting B. Favour,

Cutting B. Favour

From the Departments of Surgery, Harvard Medical School and the Peter Bent Brigham Hospital, Boston

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Somers H. Sturgis,

Somers H. Sturgis

From the Departments of Surgery, Harvard Medical School and the Peter Bent Brigham Hospital, Boston

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With the Technical Assistance of Aurelia C. Koros and Frances Mao

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Author and Article Information

Melvin M. Ketchel

From the Departments of Surgery, Harvard Medical School and the Peter Bent Brigham Hospital, Boston

Cutting B. Favour

From the Departments of Surgery, Harvard Medical School and the Peter Bent Brigham Hospital, Boston

Somers H. Sturgis

From the Departments of Surgery, Harvard Medical School and the Peter Bent Brigham Hospital, Boston

With the Technical Assistance of Aurelia C. Koros and Frances Mao

Received: October 06 1957

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1958, by The Rockefeller Institute for Medical Research New York

1958

J Exp Med (1958) 107 (2): 211–218.

https://doi.org/10.1084/jem.107.2.211

Hydrocortisone inhibits the ameboid migration of human leucocytes when added in vitro. The dose-response curve for the reaction between this steroid and leucocytes can be best expressed by a logarithmic plot of the steroid concentrations.

Tetrahydrocortisone and desoxycorticosterone had no effect on in vitro leucotyte migration.

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Copyright, 1958, by The Rockefeller Institute for Medical Research New York

1958

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