HOMOLOGOUS IMMUNOLOGICAL STUDIES OF OCULAR LENS I. IN VITRO OBSERVATIONS

Halbert , S. P.; Locatcher-Khorazo , D.; Swick , L.; Witmer , R.; Seegal , B.; Fitzgerald , P.

doi:10.1084/jem.105.5.439

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Article| May 01 1957

HOMOLOGOUS IMMUNOLOGICAL STUDIES OF OCULAR LENS : I. IN VITRO OBSERVATIONS

S. P. Halbert,

S. P. Halbert

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

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D. Locatcher-Khorazo,

D. Locatcher-Khorazo

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

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L. Swick,

L. Swick

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

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R. Witmer,

R. Witmer

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

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B. Seegal,

B. Seegal

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

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P. Fitzgerald

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

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Author and Article Information

S. P. Halbert

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

D. Locatcher-Khorazo

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

L. Swick

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

R. Witmer

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

B. Seegal

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

P. Fitzgerald

From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York

Received: January 22 1957

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1957, by The Rockefeller Institute for Medical Research New York

1957

J Exp Med (1957) 105 (5): 439–452.

https://doi.org/10.1084/jem.105.5.439

Five lens antigens of rabbits can induce antibodies homologously as evidenced by agar precipitin technics.

Cross-reactions of lenses of other species (organ specificity) may be due to similarity of varying numbers of these antigens.

Newborn and 26-day embryo rabbit lenses seem to have decreased concentrations of, or lack, one antigen present in adult rabbit lens.

Streptolysin "O" concentrates appear to act as an adjuvant for homologous lens immunization in rabbits.

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Copyright, 1957, by The Rockefeller Institute for Medical Research New York

1957

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