THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME

Skeggs , Leonard T.; Kahn , Joseph R.; Shumway , Norman P.

doi:10.1084/jem.103.3.295

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Article| March 01 1956

THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME

Leonard T. Skeggs, Jr.,

Leonard T. Skeggs, Jr.

From the Department of Medicine and Surgery, Veterans Administration Hospital, and the Department of Pathology, Western Reserve University, Cleveland

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Joseph R. Kahn,

Joseph R. Kahn

From the Department of Medicine and Surgery, Veterans Administration Hospital, and the Department of Pathology, Western Reserve University, Cleveland

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Norman P. Shumway

From the Department of Medicine and Surgery, Veterans Administration Hospital, and the Department of Pathology, Western Reserve University, Cleveland

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Author and Article Information

Leonard T. Skeggs, Jr.

From the Department of Medicine and Surgery, Veterans Administration Hospital, and the Department of Pathology, Western Reserve University, Cleveland

Joseph R. Kahn

From the Department of Medicine and Surgery, Veterans Administration Hospital, and the Department of Pathology, Western Reserve University, Cleveland

Norman P. Shumway

From the Department of Medicine and Surgery, Veterans Administration Hospital, and the Department of Pathology, Western Reserve University, Cleveland

Received: November 13 1955

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1956, by The Rockefeller Institute for Medical Research New York

1956

J Exp Med (1956) 103 (3): 295–299.

https://doi.org/10.1084/jem.103.3.295

It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II.

An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described.

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Copyright, 1956, by The Rockefeller Institute for Medical Research New York

1956

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