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Journal Articles

Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form

Xiang Deng, Gary A. Bradshaw, Marian Kalocsay, Timothy Mitchison
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (12): e202502192.
https://doi.org/10.1083/jcb.202502192
Published: 31 October 2025
View article titled, Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form
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Includes: Supplementary data
Journal Articles

SCFFBXO21-mediated ubiquitination and degradation of NMNAT2 regulates axon survival in nerve injury

In Special Collection:
Cellular Neurobiology 2025
Wenjing Long, Shunyi Li, Qiangqiang Wang, Wenkai Yue, Yanbin Fu, Haiqiong Wang, Mingsheng Jiang, Xianyan Hu, Yunxia Li, Jihong Cui, Ang Li, Yaoyang Zhang, Zairong Zhang, Yanshan Fang
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (11): e202501072.
https://doi.org/10.1083/jcb.202501072
Published: 30 September 2025
View article titled, SCFFBXO21-mediated ubiquitination and degradation of NMNAT2 regulates axon survival in nerve injury
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Includes: Supplementary data
Journal Articles

Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins

Minami Hasegawa-Ogawa, Asako Onda-Ohto, Takumasa Nakajo, Arisa Funabashi, Ayane Ohya, Ryota Yazaki, Hirotaka James Okano
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (10): e202406097.
https://doi.org/10.1083/jcb.202406097
Published: 08 August 2025
View article titled, Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins
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Includes: Supplementary data
Journal Articles

Ubiquitin chain variability directs substrates of the Tul1 ubiquitin ligase complex to different degradation pathways

Devon D. Dennison, Ryan D. Baldridge
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (9): e202312133.
https://doi.org/10.1083/jcb.202312133
Published: 22 July 2025
View article titled, Ubiquitin chain variability directs substrates of the Tul1 ubiquitin ligase complex to different degradation pathways
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Includes: Supplementary data
Journal Articles

Ubiquitin-SUMO tag-team wrestles acute promyelocytic leukemia

Alfred C.O. Vertegaal
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (6): e202504010.
https://doi.org/10.1083/jcb.202504010
Published: 09 May 2025
View article titled, Ubiquitin-SUMO tag-team wrestles acute promyelocytic leukemia
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Journal Articles

A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome

Mao Mao, Yoshihiro Ishikawa, Cassandre Labelle-Dumais, Xiaowei Wang, Yien-Ming Kuo, Uma B. Gaffney, Megan E. Smith, Carlie N. Abdala, Matthew D. Lebedev, William J. Paradee, Douglas B. Gould
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (6): e202409153.
https://doi.org/10.1083/jcb.202409153
Published: 25 April 2025
View article titled, A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome
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Includes: Supplementary data
Journal Articles

PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Anna Plechanovová, Alejandro Rojas-Fernandez, Julio C.Y. Liu, Niels Mailand, Adel F.M. Ibrahim, Graeme Ball, Iain M. Porter, Ronald T. Hay
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (6): e202407133.
https://doi.org/10.1083/jcb.202407133
Published: 16 April 2025
View article titled, PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways
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Includes: Supplementary data
Journal Articles

Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 ubiquitination

Jianlan Gu, Mingming Yang, Liti Zhang, Yuxiao Liu, Ruolan Yan, Danmin Pan, Xiaowei Qian, Hanjing Hu, Dandan Chu, Chen Hu, Fei Liu, Hengxiang Cui
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (5): e202405142.
https://doi.org/10.1083/jcb.202405142
Published: 09 April 2025
View article titled, Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 ubiquitination
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Includes: Supplementary data
Journal Articles

ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates

In Special Collection:
Cellular Neurobiology 2025
Yusen Men, Shoshiro Hirayama, Shinpei Ao, Yasuyuki Sakurai, Yuri Shibata, Megan Lo, Yusuke Sato, Shigeo Murata
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (6): e202406120.
https://doi.org/10.1083/jcb.202406120
Published: 08 April 2025
View article titled, ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates
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Includes: Supplementary data
Journal Articles

Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase

Lauren E. Vostal, Noa E. Dahan, Matthew J. Reynolds, Lily I. Kronenberg, Tarun M. Kapoor
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (5): e202410148.
https://doi.org/10.1083/jcb.202410148
Published: 14 March 2025
View article titled, Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase
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Includes: Supplementary data
Journal Articles

Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import

In Special Collection:
The Year in Cell Biology: 2025
Ya-Ting Chang, Benjamin A. Barad, Juliette Hamid, Hamidreza Rahmani, Brian M. Zid, Danielle A. Grotjahn
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (4): e202407110.
https://doi.org/10.1083/jcb.202407110
Published: 06 March 2025
View article titled, Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import
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Journal Articles

TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells

Yasuyuki Iwasa, Sohtaroh Miyata, Takuya Tomita, Naoto Yokota, Maho Miyauchi, Ruka Mori, Shin Matsushita, Rigel Suzuki, Yasushi Saeki, Hiroyuki Kawahara
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (3): e202109010.
https://doi.org/10.1083/jcb.202109010
Published: 15 January 2025
View article titled, TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells
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Includes: Supplementary data
Journal Articles

Differential impacts of ribosomal protein haploinsufficiency on mitochondrial function

Agustian Surya, Blythe Marie Bolton, Reed Rothe, Raquel Mejia-Trujillo, Amanda Leonita, Qiuxia Zhao, Alia Arya, Yue Liu, Rekha Rangan, Yasash Gorusu, Pamela Nguyen, Can Cenik, Elif Sarinay Cenik
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (3): e202404084.
https://doi.org/10.1083/jcb.202404084
Published: 09 January 2025
View article titled, Differential impacts of ribosomal protein haploinsufficiency on mitochondrial function
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Includes: Supplementary data
Journal Articles

RACK1 MARylation regulates translation and stress granules in ovarian cancer cells

In Special Collection:
Cancer Cell Biology 2025
Sridevi Challa, Tulip Nandu, Hyung Bum Kim, Xuan Gong, Charles W. Renshaw, Wan-Chen Li, Xinrui Tan, Marwa W. Aljardali, Cristel V. Camacho, Jin Chen, W. Lee Kraus
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (2): e202401101.
https://doi.org/10.1083/jcb.202401101
Published: 06 January 2025
View article titled, RACK1 MARylation regulates translation and stress granules in ovarian cancer cells
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Includes: Supplementary data
Journal Articles

Synaptic sabotage: How Tau and α-Synuclein undermine synaptic health

Valerie Uytterhoeven, Patrik Verstreken, Eliana Nachman
Journal: Journal of Cell Biology
J Cell Biol (2024) 224 (2): e202409104.
https://doi.org/10.1083/jcb.202409104
Published: 24 December 2024
View article titled, Synaptic sabotage: How Tau and α-Synuclein undermine synaptic health
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Journal Articles

PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions

Ravi Chidambaram, Kamal Kumar, Smriti Parashar, Gowsalya Ramachandran, Shuliang Chen, Susan Ferro-Novick
Journal: Journal of Cell Biology
J Cell Biol (2024) 223 (12): e202407193.
https://doi.org/10.1083/jcb.202407193
Published: 18 November 2024
View article titled, PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions
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Includes: Supplementary data
Journal Articles

Preserve or destroy: Orphan protein proteostasis and the heat shock response

Asif Ali, Sarah Paracha, David Pincus
Journal: Journal of Cell Biology
J Cell Biol (2024) 223 (12): e202407123.
https://doi.org/10.1083/jcb.202407123
Published: 15 November 2024
View article titled, Preserve or destroy: Orphan protein proteostasis and the heat shock response
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Journal Articles

Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation

In Special Collection:
Immune Cell Biology 2025
Pei Yee Tey, Almut Dufner, Klaus-Peter Knobeloch, Jonathan N. Pruneda, Michael J. Clague, Sylvie Urbé
Journal: Journal of Cell Biology
J Cell Biol (2024) 224 (1): e202312141.
https://doi.org/10.1083/jcb.202312141
Published: 15 October 2024
View article titled, Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation
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Includes: Supplementary data
Journal Articles

Feedback control of the heat shock response by spatiotemporal regulation of Hsp70

Rania Garde, Annisa Dea, Madeline F. Herwig, Asif Ali, David Pincus
Journal: Journal of Cell Biology
J Cell Biol (2024) 223 (12): e202401082.
https://doi.org/10.1083/jcb.202401082
Published: 20 September 2024
View article titled, Feedback control of the heat shock response by spatiotemporal regulation of Hsp70
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Includes: Supplementary data
Journal Articles

Integrated stress response activator halofuginone protects mice from diabetes-like phenotypes

Shashank Rai, Maria Szaruga, Aleksandra P. Pitera, Anne Bertolotti
Journal: Journal of Cell Biology
J Cell Biol (2024) 223 (10): e202405175.
https://doi.org/10.1083/jcb.202405175
Published: 16 August 2024
View article titled, Integrated stress response activator halofuginone protects mice from diabetes-like phenotypes
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Includes: Supplementary data