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Gerald S. Shadel
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Journal Articles

FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion

Alva G. Sainz, Gladys R. Rojas, Alexandra G. Moyzis, Matthew P. Donnelly, Kailash C. Mangalhara, Melissa A. Johnson, Pau B. Esparza-Moltó, Kym J. Grae, Reuben J. Shaw, Gerald S. Shadel
Journal: Journal of Cell Biology
J Cell Biol (2025) 224 (3): e202311082.
https://doi.org/10.1083/jcb.202311082
Published: 27 January 2025
View article titled, FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion
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Includes: Supplementary data
Journal Articles

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

William Hancock-Cerutti, Zheng Wu, Peng Xu, Narayana Yadavalli, Marianna Leonzino, Arun Kumar Tharkeshwar, Shawn M. Ferguson, Gerald S. Shadel, Pietro De Camilli
Journal: Journal of Cell Biology
J Cell Biol (2022) 221 (7): e202106046.
https://doi.org/10.1083/jcb.202106046
Published: 03 June 2022
View article titled, ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
Open the PDF for ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling in another window
Includes: Supplementary data
Journal Articles

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration

Laura E. Newman, Gerald S. Shadel
Journal: Journal of Cell Biology
J Cell Biol (2018) 217 (10): 3327–3329.
https://doi.org/10.1083/jcb.201808118
Published: 28 August 2018
View article titled, Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
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Journal Articles

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence

Michael Schleicher, Benjamin R. Shepherd, Yajaira Suarez, Carlos Fernandez-Hernando, Jun Yu, Yong Pan, Lisette M. Acevedo, Gerald S. Shadel, William C. Sessa
Journal: Journal of Cell Biology
J Cell Biol (2008) 180 (1): 101–112.
https://doi.org/10.1083/jcb.200706072
Published: 14 January 2008
View article titled, Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
Open the PDF for Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence in another window
Includes: Supplementary data