Presubmission inquiries as to the suitability of a manuscript are welcome and can be sent via our online manuscript submission system. We typically respond within two days. Presubmission inquiries are intended for informal feedback on whether the scope of a manuscript is appropriate for JCB. Manuscripts will not be formally evaluated in full unless submitted via the usual process.
For authors interested in presubmission manuscript preparation support services, RUP suggests Editage. Use of this service is not mandatory for publication, does not guarantee peer review or acceptance, and you are not obliged to submit your manuscript to one of our journals if you choose to use the service.
Preparing for submission to JCB
JCB accepts format-neutral first submissions. Manuscripts do not need to be formatted according to specific journal guidelines at this stage. To submit via our online system, you will need the following files and information:
You may submit your manuscript as a single PDF or as separate files. Please ensure the title page includes all authors and affiliations. A full title, abstract, and short running title are required for submission. JCB accepts submission of Articles, Reports, and Tools. If you would like to submit a Review, Viewpoint, or Spotlight for consideration, please contact the journal office at email@example.com.
Authors should provide a cover letter describing the conceptual advance of their work, related or competing papers in press or consideration elsewhere, financial conflicts of interest, and whether submission is in response to a presubmission inquiry. Authors may request a specific editor, suitable reviewers, and up to three reviewer exclusions. Requests to exclude certain individuals will be honored when possible and if the grounds for exclusion are reasonable. If the original data in the manuscript are archived in a repository and accessible for review by editors and reviewers, please state this in your letter. If you would like the editors to consider peer reviewer comments from another journal, please include this information in your letter (as described in our Transfer policy). The cover letter will not be shared with reviewers.
The corresponding author is responsible for the integrity of all data and text described within the manuscript; archiving all data related to the manuscript and providing original data upon request; adherence to all journal policies, including disclosure of related work from all authors; appropriate author contribution descriptions and conflict of interest disclosures from all authors; getting approval from all authors for the contents of the manuscript and submission; and checking accuracy of the proofs. In some instances, it may be appropriate to have more than one corresponding author who would share the above responsibilities.
Even in cases of co-corresponding authors, one individual must be identified within our online manuscript submission system as the primary corresponding author. This individual will be the point of contact at all times with the JCB editorial and production offices and will be responsible for appropriate materials, computer code, and data sharing with the community after publication, and acting as arbiter in instances of author disputes.
Funding and financial conflicts of interest
All authors must disclose any commercial affiliations or consultancies, stock or equity interests, or patent-licensing arrangements that could be considered a conflict of interest regarding the submitted manuscript. All conflicts of interest and sources of funding should be included in the Acknowledgments section of the manuscript. We use text mining of the Acknowledgments to identify funding data for deposition with CrossRef and information sharing with funders. Therefore, it is important to use full, accurate agency names and grant numbers.
Manuscripts invited to resubmit must be formatted according to all journal guidelines. General guidelines are included below. Detailed guidelines on figure and character limits based on article type can be found in our Manuscript types section. Authors should provide high-resolution individual figure files when they resubmit their revised manuscripts.
For manuscripts submitted on or after August 2, 2021, JCB requires authors to provide Source Data used to generate figures containing gels and Western blots. Source Data will be made available to reviewers during evaluation of revised manuscripts. Source Data will also be downloadable from the corresponding figures in the published article so that readers can reanalyze them or integrate them with other data.
Source Data consist of fully uncropped and unprocessed images for each gel/blot displayed in the main and supplemental figures. Files should be submitted using the Figure Source Data option in the manuscript submission system and should not be included as Supplemental Figure files. Authors should provide one Source Data file for each figure that contains gels and/or blots. File names for Source Data figures should be alphanumeric without any spaces or special characters (i.e., SourceDataF#, where F# refers to the associated main figure number or SourceDataFS# for those associated with Supplementary figures). The lanes of the gels/blots should be labeled as they are in the associated figure, the place where cropping was applied should be marked (with a box), and molecular weight/size standards should be labeled wherever possible.
Image Resolution and Size
Source Data Figures should be provided as individual PDF files (one file per figure). Authors should endeavor to retain a minimum resolution of 300 dpi or pixels per inch (ppi). Please review our instructions for export from Photoshop, Illustrator, and PowerPoint.
Response to reviewers
Revised manuscript submissions must include a point by point response to the reviewers' comments. The response file should detail how each comment was addressed experimentally and/or textually or why it could not be/was not addressed. The response to reviewers is shared with all reviewers. Authors may include data in their responses to the reviewers that they do not wish to include in the manuscript.
Manuscript organization and formatting
The title should be less than 100 characters (including spaces). Make the title concise and accessible to a general readership. A condensed title of less than 50 characters (including spaces) is also needed.
Full author names must be provided along with their institutional affiliations where the work was done. Names, affiliations, and author order should be checked carefully before resubmission. If a change of address is imminent for any author, indicate the change and the date effective. Corresponding author(s) must be identified, with ORCID, email, and full mailing address.
Provide a short, ~40-word summary statement for the online JCB table of contents and alerts. This summary should describe the context and significance of the findings for a general readership; it should be written in the present tense and refer to the work in the third person.
Abstracts must not exceed 160 words. The abstract should describe the relevant background, key results, and conceptual significance of the findings in a way that is accessible to a broad audience. Abstracts should not include references.
The Introduction should provide sufficient background to make the article accessible to non-expert readers; it should indicate what hypotheses were tested and provide sufficient context to make the significance of the problem studied and the rationale for the experiments clear to a broad audience.
The Results section describes the experiments performed and presents the findings observed. This section should be divided into subheadings. For short Reports, the Results and Discussion sections should be combined.
The Discussion summarizes the conclusions that can be drawn from the results, as well as the implications of the research. It should place your findings in the general context of the field and discuss any limitations of the experimental approaches you used. Subheadings may be used.
Materials and methods
RUP journals are signatories of the NIH Reproducibility guidelines. There are no limits on the length of JCB Materials and methods sections. JCB does not permit supplemental Materials and methods. Materials and methods sections should be comprehensive and not simply reference a previous publication for details on how an experiment was performed. JCB does not permit citations of non–peer-reviewed publications or unpublished data in the Materials and methods section. If you feel readers would benefit from a step-by-step description of a method employed in your paper we encourage authors to consider submitting a detailed protocol to Bio-protocol.
We encourage all authors to utilize the EQUATOR network to identify appropriate reporting guidelines based on study type. Authors should refer to the BRISQ reporting guidelines for any study in which human biospecimens are used. For authors reporting animal research, we encourage use of the ARRIVE guidelines. For studies using cell lines, authors should report the source of the line, whether the line has been authenticated and how, and the mycoplasma contamination status.
All antibodies, cell lines, animals, and tools used in the manuscript should be described in full, including accession numbers for materials available in a public repository such as the Resource Identification Portal. For unique reagents such as antibodies, siRNA, primers, or other probes, authors should provide the full epitopes or sequences in the manuscript. Please list chemicals and scientific instruments used and their manufacturer.
Microscope image acquisition
The following information must be provided about the acquisition and processing of images: make and model of microscope; type, magnification, and numerical aperture of the objective lenses; temperature; imaging medium; fluorochromes; camera make and model; acquisition software; and any software used for image processing subsequent to data acquisition. Please include details and types of operations involved (e.g., type of deconvolution, 3D reconstitutions, surface or volume rendering, gamma adjustments, etc.). If you export files from a microscope or other acquisition device, be sure to use consistent file formats (8 bit, 16 bit, etc.).
Authors should provide clear, detailed descriptions of their statistical analysis in the Materials and methods section and/or figure legends, including but not limited to the statistical test used, actual p-values, number of biological and technical replicates, measure of center, and measure of variability. If an editor or peer reviewer feels it necessary, we may request expert feedback specifically on statistical analysis within the manuscript.
Supplemental material is limited to figures, tables, large datasets, and videos. JCB does not permit supplemental text other than figure and table legends. A short summary paragraph of all supplemental material must appear at the end of the Materials and methods section.
The Acknowledgments should recognize contributions from non-authors and disclose all funding sources and financial conflicts of interest. If there are no potential financial conflicts of interest, please add the following statement to the Acknowledgments section: "The authors declare no competing financial interests." (If potential conflicts are listed, the statement "The authors have no additional competing financial interests" should be added instead.)
A separate author contribution section is required following the Acknowledgments in all research manuscripts. All authors should be mentioned and designated by their full names. We encourage use of the CRediT nomenclature.
All in-text citations and references must be formatted according to the JCB Reference Guidelines. In-text citations should be Harvard style and listed alphabetically by first author’s last name in the Reference section. There is no limit to the number of references cited in a manuscript. JCB strongly encourages authors to cite the primary literature rather than review articles throughout their manuscripts.
JCB discourages citation of "data not shown," "manuscript in preparation," "manuscript submitted," etc., in any section of the manuscript. If included, "personal correspondence" must be accompanied by a signed letter of permission and may only be cited in the text.
Preprints may be cited in the text and included in the Reference section. Appropriate formatting is described in the JCB Reference Guidelines. Note that citation of a previous preprint version of the manuscript under consideration should be included as a footnote.
A term that does not appear on the JCB standard abbreviations list must be used at least three times in a paper to qualify as an abbreviation. Spell out the term on first mention, and follow it with the abbreviated form in parentheses. Supply a list of nonstandard abbreviations used in the paper, in alphabetical order, giving each abbreviation followed by its spelled-out version.
All submitted images must conform to the JCB Figure and Video Guidelines. Figures should be cited in numerical order in the text in the order they are mentioned. Figures should be prepared at publication size; whenever possible, figures will be reduced to a single-column width (85 mm). If you have any questions regarding figure preparation, please contact one of our in-house specialists at firstname.lastname@example.org. All accepted figures will go through an image screening process prior to publication, as described in our Data integrity and plagiarism section.
All submitted videos must conform to the Figure and Video Guidelines. Videos must be cited both in the Results section and in the legends of any figures that contain video stills or images related to the video. Videos are peer reviewed with the manuscript. A maximum of 10 videos may be posted for each article.
Figure and video legends
All figures and videos must have titles and detailed legends. Figure legends should contain sufficient information so that readers can understand what the data show without needing to refer back to the text. All symbols, such as arrows, must be defined in the legend. Scale bar measurements must be included in the legend. Where appropriate, legends should include any statistical test used, actual p-values, number of biological and technical replicates, measure of center, and measure of variability.
Each video legend should describe what is being shown, the cell type or tissue being viewed (including relevant cell treatments, concentration and duration, or transfection), the imaging method (e.g., time-lapse epifluorescence microscopy), what each color represents, how often frames were collected, the frames/second display rate, and the number of any figure that has related video stills or images.
Include a table number and title for each table. Insert explanatory material and footnotes below the table, designating footnotes using lowercase superscript letters reading horizontally across the table. Supply units of measure at the heads of the columns. Abbreviations that are used only in a table should be defined in the table legend. Do not divide tables into subtables.
JCB follows the abbreviations and other conventions of Scientific Style and Format: The CSE Manual for Authors, Editors, and Publishers. For chemical nomenclature, follow the Subject Index of Chemical Abstracts. Capitalize trade names and give manufacturers’ names. For drawing glycan structures using symbols, we recommend the Symbol Nomenclature for Glycans (SNFG) described in the 3rd edition of Essentials of Glycobiology and at the NCBI. Please include a citation in the methods section or in the legend of a figure using these symbols e.g, “Monosaccharide symbols follow the Symbol Nomenclature for Glycans (SNFG) (PMID 26543186, Glycobiology 25: 1323–1324, 2015; www.ncbi.nlm.nih.gov/glycans/snfg.html)”.
Gene names must be italicized. Authors must use the original name published for a gene unless they have obtained permission to rename the gene from the authors of the original study (or from a governing body such as, in the case of a yeast gene, the Saccharomyces Genome Database curator). Please follow the generally accepted rules for gene and protein nomenclature appropriate for the organism you are discussing. Gene nomenclature guidelines for humans (http://www.genenames.org/about/guidelines), rats and mice (http://www.informatics.jax.org/mgihome/nomen/gene.shtml), frogs (http://www.xenbase.org/gene/static/geneNomenclature.jsp), zebrafish (https://wiki.zfin.org/display/general/ZFIN+Zebrafish+Nomenclature+Guidelines), Drosophila (http://flybase.org/wiki/FlyBase:Nomenclature), C. elegans (http://www.wormbase.org#012-34-5), and Arabidopsis (https://www.arabidopsis.org/portals/nomenclature/guidelines.jsp) are available at the indicated sites.
Before we can accept your manuscript, the files and information below must be received by the editorial office.
High-resolution, editable, individual figure files are required, preferably in the original file format in which they were created. The manuscript text must be provided as a DOC or DOCX file.
Review process file publication
Authors have the option to publish an online supplementary document with all formal correspondence between authors and editors for accepted manuscripts that were directly submitted to Journal of Cell Biology. Referee anonymity will be maintained. If you wish to have this information published with your manuscript and would prefer data specifically included in the response to referees but intended for publication elsewhere to be redacted from the document, please provide an appropriately revised version of your rebuttal document when submitting the final files.
License to publish
A license to publish must be signed by the primary corresponding author prior to acceptance. View our license to publish agreement for more details.
If you are using previously published images in your manuscript, please see our permissions page for guidance.
RUP supports universal adoption of digital name identifiers to aid name disambiguation. ORCID identifiers are required of corresponding authors prior to publication and encouraged for all co-authors. You’ll be prompted to provide ORCID identifiers by our submission software. Once ORCIDs are added to our system, they will be automatically populated for all future submissions. You can also use your ORCID to log in to our submission system. Your article will be automatically listed in your ORCID record upon publication. Learn more about ORCID and the benefits of registering here.
Authors whose manuscripts are accepted for publication may submit cover images and a brief legend for consideration. Images submitted should be at least 300 dpi at the size of publication (8.75" W x 11.25" H). Please submit cover suggestions via our online manuscript submission system when you upload final files prior to editorial acceptance.
Authors may include a Graphical Abstract with their manuscript. A Graphical Abstract is a single, concise, and self-explanatory visual summary of the main findings of the article that should capture the content of the article at a single glance. If provided, the Graphical Abstract will be available online only and will be used in all social media promotions to highlight the manuscript. Please follow our detailed instructions when creating your Graphical Abstract.
Production and proofs
After acceptance, your manuscript will be sent to production for copy editing and preparation of the proofs. If you will be unavailable at any time while your manuscript is in production, please contact email@example.com.
Corresponding authors will be emailed a link to proofs within two weeks after acceptance. Authors may choose to edit either the HTML or PDF versions of their proofs. Proofs must be returned within 48 hours.
Articles are usually published within 48 hours after the author returns corrected proofs. This can vary depending on the extent of requested changes. Publication date also depends on whether the article has a companion article or press coverage. On publication day, the articles are usually posted before 10AM EST. See our FAQ on daily publication for more details.
Authors will be charged a $2,000 flat fee for all publication charges. An author's inability to pay these charges will not affect the publication of acceptable manuscripts.
Authors have the option to instead pay a single article charge of $5,300 in order to make their article open access immediately upon publication under CC-BY license.
Reprints and journal copies
You will have the opportunity to order paper reprints of your article, print copies of the issue in which your manuscript will appear, or cover posters when you return your proofs.
Copyright of all material published in RUP journals remains with the authors. Unless immediate open access is selected, authors grant Rockefeller University Press an exclusive license to publish their work for the first six months. After six months, the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license (CC-BY-NC-SA).
If immediate open acess is selected, upon publication the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Share Alike 4.0 International license (CC-BY).
Authors wishing to appeal an editorial decision should do so through the online manuscript submission system by clicking on the “Submit Appeal” link in the relevant manuscript record. A rebuttal letter and—if appropriate—a point by point response to the reviewers should be provided. A decision is usually communicated to the authors within 10 days. Please note that editors prioritize handling new submissions that have not yet received a first decision over appeals. JCB does not allow multiple appeals on a manuscript.
Corrections and refutations
Corrections will be published at the discretion of the editors. Contact the journal office at firstname.lastname@example.org to request a correction to a published article.
JCB considers submissions aimed at refuting conclusions previously published in the journal. Such manuscripts should provide direct and definitive evidence that the conclusions in a previous JCB paper are incorrect. Please indicate in your cover letter that your manuscript is submitted as a refutation. The refutation will be peer reviewed, and the authors of the original work will be given the opportunity to submit a response for editorial consideration. Manuscripts that describe differing observations or draw different conclusions than past work through the use of new approaches or tools are a normal part of the scientific discourse and will not be considered as refutations. For more information, please contact the JCB editorial office at email@example.com.
Annotation and Comments
JCB allows public commenting on all published articles using the Hypothesis annotation tool. Submitted comments should be constructive, factual, collegial, and relevant to the paper being discussed. Users must use their full name when posting comments. All comments are moderated by our editors prior to posting. Any content determined to be inappropriate will not be posted. Learn more about Hypothesis here.
Aims and scope
Front matter formats
Author name changes
Animal and human studies
Data integrity and plagiarism
Materials and data sharing
Conflict of interest
Peer review correspondence