Aguilera et al. show that ferroptosis, an oxidative and iron-dependent form of regulated cell death, plays an important role in the cyanobacterium Synechocystis sp. PCC 6803 in response to heat stress.
Human atlastin GTPases are assumed to catalyze ER membrane fusion, but their fusion activity has not previously been reconstituted. Crosby et al. show that purified atlastin1 and atlastin2 are capable of fusion catalysis and that each is negatively regulated by a variable C-terminal extension.
Uchino et al. have developed a genetically encoded probe to specifically detect the Ser2-phosphorylated, elongating form of RNA polymerase II in living cells. Ser2-phosphorylated RNA polymerase foci exhibit more dynamic motion than chromatin replication domains and p300-enriched foci.