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Issues

ISSN 0021-9525
EISSN 1540-8140
In this Issue

Article

Chapa-y-Lazo et al. report that, during anaphase, astral microtubules and dynein remove myosin from the non-equatorial cell cortex and trigger a bidirectional cortical flow toward the equator, which facilitates assembly of the actomyosin contractile ring.

Autophagosomes engulf a variety of targets, from a portion of cytosol to large organelles, by regulating the size of the autophagosomal membrane. Yamamoto et al. identify ERdj8, a novel ER membrane protein that affects the size of autophagosomes.

Report

Sas4 is a conserved basal body assembly protein. Here, Ruehle et al. describe a previously unknown link between basal bodies and the control of cell division by Hippo signaling molecules that depends on Sas4.

Article

Trafficking of matrix metalloproteinases (MMPs) through the Golgi remains enigmatic in the field. Pacheco-Fernandez et al. find that nucleobindin-1 (NUCB1), a cis-Golgi localized Ca2+-binding protein, plays a major role in this process by binding to MMPs, regulating their intra-Golgi trafficking, and thereby modulating cell invasion and matrix degradation.

Report

Magliozzi et al. show that fission yeast cell polarity kinase Pak1 regulates cytokinesis. Through a phosphoproteomic screen and subsequent mutant analysis, their work uncovers direct targets and mechanisms for Pak1 activity during cell division.

Rsp5 is an E3 ubiquitin ligase of the Nedd4 family that regulates many cellular processes in yeast. Zhu et al. show that two paralogous Rsp5 adaptors, Rcr1 and Rcr2, are sorted to distinct locations. Exomer sorts Rcr1 to the plasma membrane via a new sorting motif, and the upregulation of Rcr1 via the calcineurin/Crz1 signaling pathway maintains cell integrity.

To segregate chromosomes, the mammalian spindle must generate and respond to force. How it does so remains poorly understood. Pulling on the spindle using microneedles, Long et al. show that it can locally dissipate sustained force by regulating microtubule dynamics and breakage, thereby preserving global spindle structure.

Article

Cancer cell dissemination is facilitated by small actin-rich plasma membrane protrusions called invadopodia. Pedersen et al. now show that invadopodia maturation and function depend on contact site formation between the endoplasmic reticulum and late endosomes, which promotes translocation of the latter to growing invadopodia.

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