On the cover
Developing spermatids in the Drosophila testis. Ana1 (pink) and Sas-6 (cyan) mark basal bodies attached to individual spermatid nuclei (blue). Each basal body has a flagella (yellow) extending from its distal end. Galletta et al. show that the centriole protein Asterless regulates centriole length and basal body function.
Image courtesy of Katherine C. Jacobs.
© 2016 Galletta et al.
See page 435.
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The diaphanous formin mDia2, a protein involved in cytoskeletal control, is required for new CENP-A loading at centromeres during the cell cycle to maintain epigenetic markers.
The tubulin gene family encodes multiple tubulin isotypes that can have distinct polymerization properties. Pamula et al. show that residue changes within β tubulin’s structured core are largely responsible for isotype-specific differences in dynamic instability.
Loss of the centriole protein Asterless (Asl) prevents centriole duplication, which has limited the study of its function at centrioles. Here, Galletta et al. show that Asl controls centriole length and ensures proper basal body functions during spermatogenesis.
Wang et al. identify that DSCR1, a gene on chromosome 21 that is associated with Down syndrome, controls both the rate and direction of axon growth in response to extrinsic cues by regulating cytoskeletal dynamics and local protein synthesis in the growth cone.
The transcription factors Mesp1 and Mesp2 are equally efficient at promoting specification, EMT, and differentiation of early multipotent cardiovascular progenitors. However, only Mesp1 promotes the speed, polarity, and directionality of cell migration, explaining how Mesp1 coordinates progenitor fate decision and migration during development.
Chloride is ubiquitous in physiology but understood to provide ionic strength for tissue function. The authors discover a molecular function of chloride whereby the ion signals the assembly of collagen IV, establishing a microenvironment on the outside of cells.