Issues

Researchers investigate how developmental changes in subunit composition allow septins to perform different functions.

Feldman studies how cell patterning and cytoskeletal organization are controlled.

Cytokinetic abscission, the final stage of cell division, is mediated by the ESCRT machinery. Here, Christ et al. dissect the regulation of ESCRT-III recruitment and abscission timing and identify an intersection with abscission checkpoint signaling in cells with chromatin bridges.

Analysis of the contribution of meiotic septins Spr3 and Spr28 to overall septin complex architecture at the ultrastructural level provides insights into how alternative subunits endow septin complexes with unique properties.

Drp1-dependent mitochondrial fission through MiD49 and MiD51, but not through Mff, is essential for cristae remodeling to facilitate cytochrome c release during the early phase of intrinsic apoptosis.

Comparison of autophagy inhibition by deletion of Atg5, Atg16L1, Atg7, or Fip200 reveals a critical role for increased p62 in determining the fate of autophagy-deficient neural stem cells by controlling intracellular superoxide.

Cellular rearrangements between olfactory cells and supporting cells, driven by the different expression and distribution of nectins and cadherins, are required for mosaic cellular patterning in the olfactory epithelium.

The selective autophagy cargo receptor NBR1 enhances the disassembly of cell-matrix focal adhesions during cell migration.

The atypical cadherin Fat2 binds the WAVE regulatory complex (WRC) and acts with receptor tyrosine phosphatase Dlar through the WRC to control collective cell migration during Drosophila oogenesis.