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    Pseudocolored images of a single cell C. elegans embryo show the distribution of F-actin (visualized with a GFP-tagged actin-binding domain from Utrophin) during cytokinesis. Jordan et al. reveal that cortical PAR proteins promote robust cytokinesis during the embryo’s first asymmetric division.
    Image © 2016 Jordan et al.
    See page 39.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

The ubiquitin ligase TRAIP helps cells restart stalled replication forks.

People & Ideas

Dent studies how chromatin-modifying proteins regulate development and cancer.



PML-II plays a critical role in generating nuclear lipid droplets, which are associated with promyelocytic leukemia nuclear bodies as well as with the extension of the inner nuclear membrane.

In asymmetrically dividing C. elegans embryos, the core cortical PAR proteins are required to retain septin and anillin at the anterior cortex away from the contractile ring and to promote normal F-actin levels at the contractile ring and successful cytokinesis.

Zds1/Zds2–PP2ACdc55 forms a complex with Rho1 GTPase and specifies Rho1 signaling outcome by regulating Rho1 GAPs in budding yeast.


The E3 ubiquitin ligase TRAIP associates with replication forks through direct interaction with PCNA, promoting checkpoint signaling and genome stability after replication stress.

Polycomb complex member Cbx4 represses nonepidermal lineage and cell cycle inhibitor genes in the epidermal keratinocytes and operates as a direct p63 target, maintaining epithelial identity and proliferative activity in the developing epidermis.


NeuriteTracker is a computer vision approach used to analyze neuronal morphodynamics and to examine spatiotemporal Rho GTPase signaling networks regulating neurite outgrowth.

A synthetic ECM-mimetic hydrogel platform with independent control over adhesive ligand density, mechanical properties, and proteolytic degradation provides a valuable tool to study how cells transduce ECM properties into morphogenetic behaviors.

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