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Cover Image
Cover Image
On the cover
Pseudocolored images of a single cell C. elegans embryo show the distribution of F-actin (visualized with a GFP-tagged actin-binding domain from Utrophin) during cytokinesis. Jordan et al. reveal that cortical PAR proteins promote robust cytokinesis during the embryo’s first asymmetric division.
Image © 2016 Jordan et al.
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In This Issue
In Focus
Taking the stress out of replication
The ubiquitin ligase TRAIP helps cells restart stalled replication forks.
People & Ideas
Sharon Dent: The unfolding SAGA of chromatin-modifying proteins
Dent studies how chromatin-modifying proteins regulate development and cancer.
Review
Report
PML isoform II plays a critical role in nuclear lipid droplet formation
PML-II plays a critical role in generating nuclear lipid droplets, which are associated with promyelocytic leukemia nuclear bodies as well as with the extension of the inner nuclear membrane.
Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division
In asymmetrically dividing C. elegans embryos, the core cortical PAR proteins are required to retain septin and anillin at the anterior cortex away from the contractile ring and to promote normal F-actin levels at the contractile ring and successful cytokinesis.
Zds1/Zds2–PP2ACdc55 complex specifies signaling output from Rho1 GTPase
Zds1/Zds2–PP2ACdc55 forms a complex with Rho1 GTPase and specifies Rho1 signaling outcome by regulating Rho1 GAPs in budding yeast.
Article
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
The E3 ubiquitin ligase TRAIP associates with replication forks through direct interaction with PCNA, promoting checkpoint signaling and genome stability after replication stress.
Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium
Polycomb complex member Cbx4 represses nonepidermal lineage and cell cycle inhibitor genes in the epidermal keratinocytes and operates as a direct p63 target, maintaining epithelial identity and proliferative activity in the developing epidermis.
Tools
Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling
NeuriteTracker is a computer vision approach used to analyze neuronal morphodynamics and to examine spatiotemporal Rho GTPase signaling networks regulating neurite outgrowth.
Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis
A synthetic ECM-mimetic hydrogel platform with independent control over adhesive ligand density, mechanical properties, and proteolytic degradation provides a valuable tool to study how cells transduce ECM properties into morphogenetic behaviors.
