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In This Issue

In Focus

Two studies describe how nucleoporins affect muscle differentiation and budding yeast lifespan.

People & Ideas

Ivaska has taken the road less traveled to show how integrin inactivation regulates cell migration and invasion.




Phosphorylation of SPAT-1/Bora by Cdk1 enhances Plk1 phosphorylation by Aurora A and promotes entry into mitosis in C. elegans.

The luminal domain of Nup210 that lacks NPC sorting signals is sufficient for myogenesis, which suggests that Nup210 may operate within the nuclear envelope/ER lumen during differentiation.

CRISPR–Cas9-induced mutations in intraflagellar transport (IFT) motors reveal that IFT-specific dynein and cytoplasmic dynein have unique compositions but share components and regulatory mechanisms.

Centrin2 is required for efficient ciliogenesis in lymphocytes and epithelial cells through the removal of the ciliation inhibitor CP110.

Lipolysis-stimulated lipoprotein receptor, a component of the paracellular barrier at tricellular junctions, is necessary for proper blood–brain barrier sealing during embryogenesis.


During mitosis, Aurora B is necessary for telomere dispersion through effects on Swi6/HP1 and cohesin and for subsequent telomere disjunction and chromosome arm separation through effects on condensin.

Specific nucleoporins and nuclear pore complex–dependent transport events directly influence aging in yeast.

Cell growth relies on Hrr25/CK1δ-directed phosphorylation of Ltv1, which allows its release from nascent 40S ribosomal subunits and promotes subunit maturation.

Cell-specific gene inactivation experiments delineate the functions of the enzymes required for osteocalcin modification and demonstrate that it is its uncarboxylated form that acts as a hormone.

NORE1A is a Ras senescence effector that modulates HIPK2-dependent posttranslational modifications of p53.

Cholesterol acts as a sensor of NMDA receptor activation and as a trigger of downstream signaling by engaging small GTPase activation and AMPA receptor synaptic delivery during long-term potentiation.

In response to injury, Hedgehog signaling regulates the production of Upd2 in enteroblasts, which in turn activates the JAK–STAT pathway to drive intestinal stem cell proliferation.

In Special Collection: JCB65: Cell Adhesion and Migration

ZO-1 regulates VE-cadherin–dependent endothelial junctions and actomyosin organization, thereby influencing cell–cell tension, migration, angiogenesis, and barrier formation

In Xenopus and zebrafish gastrulae, PAPC attenuates planar cell polarity signaling and controls formation of an adhesive, yet flexible, contact at the ectoderm–mesoderm boundary.


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