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Cover Image
Cover Image
On the cover
Sohet et al. reveal that the tricellular tight junction protein LSR is required to seal the blood-brain barrier during embryogenesis. In a mouse brain blood vessel (green), LSR (red) localizes to the points where three endothelial cells meet, whereas occludin blue) localizes to bicellular tight junctions.
Image © 2015 Sohet et al.
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In This Issue
In Focus
Adding complexity to the nuclear pore complex
Two studies describe how nucleoporins affect muscle differentiation and budding yeast lifespan.
People & Ideas
Johanna Ivaska: Finding opposing forces in integrins
Ivaska has taken the road less traveled to show how integrin inactivation regulates cell migration and invasion.
Feature
Review
Report
Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos
Phosphorylation of SPAT-1/Bora by Cdk1 enhances Plk1 phosphorylation by Aurora A and promotes entry into mitosis in C. elegans.
The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis
The luminal domain of Nup210 that lacks NPC sorting signals is sufficient for myogenesis, which suggests that Nup210 may operate within the nuclear envelope/ER lumen during differentiation.
Somatic CRISPR–Cas9-induced mutations reveal roles of embryonically essential dynein chains in Caenorhabditis elegans cilia
CRISPR–Cas9-induced mutations in intraflagellar transport (IFT) motors reveal that IFT-specific dynein and cytoplasmic dynein have unique compositions but share components and regulatory mechanisms.
Centrin2 regulates CP110 removal in primary cilium formation
Centrin2 is required for efficient ciliogenesis in lymphocytes and epithelial cells through the removal of the ciliation inhibitor CP110.
LSR/angulin-1 is a tricellular tight junction protein involved in blood–brain barrier formation
Lipolysis-stimulated lipoprotein receptor, a component of the paracellular barrier at tricellular junctions, is necessary for proper blood–brain barrier sealing during embryogenesis.
Article
Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction
During mitosis, Aurora B is necessary for telomere dispersion through effects on Swi6/HP1 and cohesin and for subsequent telomere disjunction and chromosome arm separation through effects on condensin.
Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae
Specific nucleoporins and nuclear pore complex–dependent transport events directly influence aging in yeast.
Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth
Cell growth relies on Hrr25/CK1δ-directed phosphorylation of Ltv1, which allows its release from nascent 40S ribosomal subunits and promotes subunit maturation.
GGCX and VKORC1 inhibit osteocalcin endocrine functions
Cell-specific gene inactivation experiments delineate the functions of the enzymes required for osteocalcin modification and demonstrate that it is its uncarboxylated form that acts as a hormone.
NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2
NORE1A is a Ras senescence effector that modulates HIPK2-dependent posttranslational modifications of p53.
LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery
Cholesterol acts as a sensor of NMDA receptor activation and as a trigger of downstream signaling by engaging small GTPase activation and AMPA receptor synaptic delivery during long-term potentiation.
Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells
In response to injury, Hedgehog signaling regulates the production of Upd2 in enteroblasts, which in turn activates the JAK–STAT pathway to drive intestinal stem cell proliferation.
ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation
ZO-1 regulates VE-cadherin–dependent endothelial junctions and actomyosin organization, thereby influencing cell–cell tension, migration, angiogenesis, and barrier formation
PAPC mediates self/non–self-distinction during Snail1-dependent tissue separation
In Xenopus and zebrafish gastrulae, PAPC attenuates planar cell polarity signaling and controls formation of an adhesive, yet flexible, contact at the ectoderm–mesoderm boundary.
