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In This Issue

In Focus

Studies reveal mechanisms that reverse and then reactivate replication forks.

People & Ideas

Horwitz is leading the Allen Institute for Cell Science in its quest to comprehend the cell.

From the Archive

In 1981, Pollard and Mooseker used electron microscopy to measure the rate of actin polymerization.


Beyond the Cell


Sall4 is important for the activation of ATM-dependent cellular responses to DNA double-stranded breaks (DSBs) in mouse embryonic stem cells and confers resistance to DSB-induced cytotoxicity.

New roles for the N-terminal histone tail and folded core of CENP-A are revealed by monitoring early steps in centromere establishment.

Transcripts encoding polarity factors such as Bni1 and Spa2 are nonrandomly clustered in the cytosol to initiate and maintain sites of polarized growth in the fungus Ashbya gossypii.


In Special Collection: JCB65: DNA Replication and Repair

Following prolonged genotoxic stress, DNA2 and WRN functionally interact to degrade reversed replication forks and promote replication restart, thereby preventing aberrant processing of unresolved replication intermediates

In Special Collection: JCB65: DNA Replication and Repair

Genotoxic treatments in human cells consistently induce uncoupling of replication forks and their remodeling into four-way junctions by the RAD51 recombinase.

Recurrent supra-ribosomal building blocks separated by ribosome-free mRNA regions form polysomes and reflect cellular translational activity.

Phosphorylation and methylation of desmoplakin are required for proper junction assembly and adhesion strengthening, and inhibition of these modifications might contribute to skin and heart diseases.

Interaction between K17 and hnRNP K regulates CXCR3 signaling in an RSK-dependent fashion to promote epithelial tumor cell growth and invasion.

DENND2B, in a complex with the Rab13 effector MICAL-L2, activates Rab13 at the cell periphery, promoting the dynamic remodeling of the cell’s leading edge during tumor cell migration both in vitro and in vivo.

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