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Cover Image
Cover Image
On the cover
Albrecht et al. demonstrate that phosphorylation and methylation of the desmosomal protein desmoplakin is required for the proper assembly of intercellular adhesions. A mutation linked to arrhythmogenic cardiomyopathy abolishes one of desmoplakin’s methylation sites, and a version of the protein carrying this mutation (green) shows increased association with keratin intermediate filaments (red), thereby delaying its assembly into intercellular junctions. DNA is labeled blue.
Image © 2015 Albrecht et al.
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In This Issue
In Focus
A fresh start for stalled forks
Studies reveal mechanisms that reverse and then reactivate replication forks.
People & Ideas
Rick Horwitz: Words do not suffice
Horwitz is leading the Allen Institute for Cell Science in its quest to comprehend the cell.
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Article
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Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes
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GSK3- and PRMT-1–dependent modifications of desmoplakin control desmoplakin–cytoskeleton dynamics
Phosphorylation and methylation of desmoplakin are required for proper junction assembly and adhesion strengthening, and inhibition of these modifications might contribute to skin and heart diseases.
Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes
Interaction between K17 and hnRNP K regulates CXCR3 signaling in an RSK-dependent fashion to promote epithelial tumor cell growth and invasion.
DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior
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