On the cover
Cain et al. show that large gaps form between the inner and outer nuclear membranes of body wall muscle cells in C. elegans lacking the SUN protein UNC-84. On the other hand, the LINC complexes formed by SUN and KASH proteins are not required to maintain nuclear envelope spacing in cell types not subject to mechanical stress.
Image © 2014 Cain et al.
See page 163.
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The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture
SUN-KASH bridges that connect the nucleoskeleton to the cytoskeleton are only required to maintain nuclear envelope spacing in cells subjected to increased mechanical forces, such as muscle cells.
The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation
To meet their metabolic needs, starved cells first activate autophagy, but activation in parallel of the general amino acid control pathway increases amino acid uptake, leading to reactivation of mTOR and down-regulation of autophagy.
Deubiquitination of Rad18 drives its localization to sites of DNA damage and formation of the Rad18–SHPRH complexes necessary for error-free lesion bypass.
When temperature fluctuation threatens the fidelity of Drosophila oogenesis, Klar restrains posterior-ward translocation of oskar mRNA, thereby adapting the rate of oskar delivery to the capacity of the anchoring machinery.
The endonuclease AGO3 and mitochondria-associated protein Zucchini together control the dynamic subcellular localization of Armitage between mitochondria and germline granules to regulate secondary piRNA amplification.
In the absence of continuous K-fiber attachment between each kinetochore and the spindle pole, one or more additional mechanisms dependent on dynein-mediated kinetochore transport exist to ensure proper chromosome segregation during mitosis.
After the loss of continuous spindle microtubule attachment to the spindle pole, a previously undescribed mechanism of chromosome transport, powered by dynein pulling on minus ends of severed microtubules, repairs spindle architecture and integrity.
Centrosome–microtubule interactions during interphase are important for centrosome clustering and cell polarity.
Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly
Palmitoylation of ankyrin-G and interaction of βII-spectrin with phosphoinositides are necessary for ankyrin-G–βII-spectrin localization in membrane subdomains during lateral membrane assembly in columnar epithelial cells.
Sirtuin-mediated deacetylation of the catalytic subunit of mitochondrial complex V increases complex activity.
A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination
RAB5A and RAB4 promote breast tumor cell dissemination by controlling the trafficking of proteins necessary for localized invadosome formation.