On the cover
A HeLa cell plated onto an L-shaped, fibronectin-coated micropattern forms prominent retraction fibers containing F-actin (green) that help to orient the mitotic spindle. Machicoane et al. reveal that spindle orientation is promoted by the SLK kinase–dependent activation of the actin-binding ezrin/radixin/moesin (ERM) family.
Image © 2014 Machicoane et al.
See page 791.
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During osteoclast differentiation, two extracellular cues that induce cAMP production both converge on HDAC4 and induce Rankl expression but do so using distinct signaling pathways.
ERM activation by SLK kinase promotes polarized association at the mitotic cortex of LGN and NuMA, a necessary step in proper spindle orientation.
The ZP251–149 domain is necessary for human and mouse gamete recognition on the surface of the zona pellucida and for mouse fertility.
Cavβ1a acts as a voltage-gated calcium channel-independent regulator of gene expression in muscle progenitor cells and is required for their normal expansion during myogenic development.
Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins
Intramembrane proteolytic cleavage by signal peptide peptidase is required for the turnover of some ER-resident, tail-anchored membrane proteins.