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    A HeLa cell plated onto an L-shaped, fibronectin-coated micropattern forms prominent retraction fibers containing F-actin (green) that help to orient the mitotic spindle. Machicoane et al. reveal that spindle orientation is promoted by the SLK kinase–dependent activation of the actin-binding ezrin/radixin/moesin (ERM) family.
    Image © 2014 Machicoane et al.
    See page 791.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study shows how actin-binding proteins help tilt the mitotic spindle.

People & Ideas

Martín-Belmonte studies epithelial morphogenesis in 3D culture and in zebrafish.



During osteoclast differentiation, two extracellular cues that induce cAMP production both converge on HDAC4 and induce Rankl expression but do so using distinct signaling pathways.

Mps1 is necessary for proper condensin II loading onto chromatin and subsequent chromosome condensation during mitosis.

ERM activation by SLK kinase promotes polarized association at the mitotic cortex of LGN and NuMA, a necessary step in proper spindle orientation.

The ZP251–149 domain is necessary for human and mouse gamete recognition on the surface of the zona pellucida and for mouse fertility.


The RAD18 E3 ligase requires SIVA1 as an accessory protein for binding to its substrate PCNA during translesion DNA synthesis.

Cavβ1a acts as a voltage-gated calcium channel-independent regulator of gene expression in muscle progenitor cells and is required for their normal expansion during myogenic development.

Intramembrane proteolytic cleavage by signal peptide peptidase is required for the turnover of some ER-resident, tail-anchored membrane proteins.

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