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Cover Image
Cover Image
On the cover
Brill et al. develop techniques to label individual Schwann cells in vivo to investigate their organization and dynamics at neuromuscular junctions. Axonal (yellow) and terminal (magenta, cyan, and green) Schwann cells are arranged around a motor axon (grey). Synaptic vesicles are shown in red. Image courtesy of Monika Brill.
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In This Issue
In Focus
Locating a mitochondrial scaffold on the map
A high-density genetic interaction map reveals a complex that organizes the mitochondrial inner membrane.
People & Ideas
Anna Akhmanova: Great tips on microtubules
Akhmanova studies microtubule plus end–binding proteins and proteins that interact with microtubule motors.
Review
Report
Probing the nucleoporin FG repeat network defines structural and functional features of the nuclear pore complex
A new tool to probe the FG repeat network of the nuclear pore complex transport channel in vivo provides insight into the organization and functional features of the channel.
High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport
High-resolution particle tracking shows a specific role for the dynein regulatory factor LIS1 in high-load axonal transport of large vesicles but no evidence for mechanical activation of opposite-directed motors.
Article
The yeast Batten disease orthologue Btn1 controls endosome–Golgi retrograde transport via SNARE assembly
Btn1 controls endosome–Golgi retrograde sorting by regulating SNARE phosphorylation and assembly.
Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation
Differential expression and activity of the cellular energy regulators GAPDH and NDPK underlie reactive oxygen species–induced damage in the mouse liver and may contribute to human liver disease progression.
The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification
The PP2A subunit Twins and the SV40 small T antigen, a functional mimic of Twins, counteract Plk4 autophosphorylation, leading to its stabilization and to subsequent centriole amplification.
Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF
The FERM domain–containing protein Lulu2 and p114RhoGEF function at epithelial cell–cell junctions to regulate the actomyosin belt that determines cell shape.
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential
To promote cell survival, the antiapoptotic factor Bcl-xL both inhibits Bax-induced mitochondrial outer membrane permeabilization and stabilizes mitochondrial inner membrane ion flux and thus overall mitochondrial energetic capacity.
Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim−/− mice
In the absence of the pro-apoptotic factor Bim, caspase-8 plays an important role in restraining autoimmunity by inducing cell death in T cells.
Spatial constraints dictate glial territories at murine neuromuscular junctions
Spatial competition between glial cells causes them to partition neuromuscular junctions into discrete domains within a synapse.
p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair
MKP-1 limits p38 MAPK signaling in macrophages to promote the resolution of the inflammatory response and tissue repair in muscle through an AKT-dependent mechanism.
Tools
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria
Statement MITO-MAP, a high-density genetic interaction map in budding yeast, identifies a mitochondrial inner membrane–associated complex that promotes normal mitochondrial membrane organization and morphology.
