On the cover
A transverse section through a mouse tibialis anterior muscle fiber shows that cytoplasmic γ-actin (green) and β2-spectrin (red) localize to the sarcoplasmic reticulum, which wraps around myofibrils (blue) and stores the calcium required for muscle contraction. Gokhin and Fowler reveal that cytoplasmic γ-actin is mislocalized in the absence of the actin-capping protein tropomodulin1, leading to impaired calcium release and myofibril misalignment.
Image courtesy of David Gokhin.
See page 105.
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In This Issue
People & Ideas
The core EMT regulatory factors Twist, Snail, Slug, and Sip1, while structurally diverse, are coordinately regulated by a common E3 ubiquiting ligase, Ppa.
POM121 and Sun1, but not the Nup107–160 complex, are required for fusion of the inner and outer nuclear membrane during nuclear pore assembly in interphase of the cell cycle.
Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
Interaction between the hydrophobic Bak BH3-binding groove and the BH3 domain of activator proteins is a key step in initiating Bak oligomerization and activation.
Sumoylation of α-synuclein decreases its rate of aggregation and its deleterious effects in vitro and in vivo.
p24 complexes act as cargo receptors for sorting GPI-anchored proteins into COPII vesicles.
α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding
Two membrane curvature–sensing molecules with opposite chemistries are targeted to distinct vesicle classes through direct interaction with different lipid environments.
Cytoplasmic γ-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers
Tropomodulins, cytoplasmic γ-actin, and small ankyrin 1.5 mechanically stabilize the sarcoplasmic reticulum and maintain myofibril alignment in skeletal muscle fibers.
A PAR-1–dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte
A PAR-1–mediated bias in microtubule organization in the Drosophila oocyte underlies posterior-directed mRNA transport.
Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC–spindle interaction to ensure proper microtubule dynamics
Ipl1/Aurora-mediated phosphorylation of the CPC component Sli15/INCENP promotes microtubule dynamics by restricting CPC–spindle association.