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Cover Image
Cover Image
On the cover
A transverse section through a mouse tibialis anterior muscle fiber shows that cytoplasmic γ-actin (green) and β2-spectrin (red) localize to the sarcoplasmic reticulum, which wraps around myofibrils (blue) and stores the calcium required for muscle contraction. Gokhin and Fowler reveal that cytoplasmic γ-actin is mislocalized in the absence of the actin-capping protein tropomodulin1, leading to impaired calcium release and myofibril misalignment.
Image courtesy of David Gokhin.
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In This Issue
In Focus
The sarcoplasmic reticulum takes on a supporting role
Membrane network keeps muscle fibrils in line.
People & Ideas
Carol Dieckmann: An eye on organellar biology
Carol Dieckmann studies the Chlamydomonas eyespot and mitochondrial gene expression.
Review
Report
The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1
The core EMT regulatory factors Twist, Snail, Slug, and Sip1, while structurally diverse, are coordinately regulated by a common E3 ubiquiting ligase, Ppa.
POM121 and Sun1 play a role in early steps of interphase NPC assembly
POM121 and Sun1, but not the Nup107–160 complex, are required for fusion of the inner and outer nuclear membrane during nuclear pore assembly in interphase of the cell cycle.
Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
Interaction between the hydrophobic Bak BH3-binding groove and the BH3 domain of activator proteins is a key step in initiating Bak oligomerization and activation.
Article
Sumoylation inhibits α-synuclein aggregation and toxicity
Sumoylation of α-synuclein decreases its rate of aggregation and its deleterious effects in vitro and in vivo.
Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI
p24 complexes act as cargo receptors for sorting GPI-anchored proteins into COPII vesicles.
Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing
The activity of siRNAs in gene silencing is regulated by protein complexes that sort cargo to lysosome-related organelles.
α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding
Two membrane curvature–sensing molecules with opposite chemistries are targeted to distinct vesicle classes through direct interaction with different lipid environments.
Cytoplasmic γ-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers
Tropomodulins, cytoplasmic γ-actin, and small ankyrin 1.5 mechanically stabilize the sarcoplasmic reticulum and maintain myofibril alignment in skeletal muscle fibers.
A PAR-1–dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte
A PAR-1–mediated bias in microtubule organization in the Drosophila oocyte underlies posterior-directed mRNA transport.
Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC–spindle interaction to ensure proper microtubule dynamics
Ipl1/Aurora-mediated phosphorylation of the CPC component Sli15/INCENP promotes microtubule dynamics by restricting CPC–spindle association.
