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  • Cover Image

    Cover Image

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    On the cover
    A transverse section through a mouse tibialis anterior muscle fiber shows that cytoplasmic γ-actin (green) and β2-spectrin (red) localize to the sarcoplasmic reticulum, which wraps around myofibrils (blue) and stores the calcium required for muscle contraction. Gokhin and Fowler reveal that cytoplasmic γ-actin is mislocalized in the absence of the actin-capping protein tropomodulin1, leading to impaired calcium release and myofibril misalignment.
    Image courtesy of David Gokhin.
    See page 105.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Membrane network keeps muscle fibrils in line.

People & Ideas

Carol Dieckmann studies the Chlamydomonas eyespot and mitochondrial gene expression.



The core EMT regulatory factors Twist, Snail, Slug, and Sip1, while structurally diverse, are coordinately regulated by a common E3 ubiquiting ligase, Ppa.

POM121 and Sun1, but not the Nup107–160 complex, are required for fusion of the inner and outer nuclear membrane during nuclear pore assembly in interphase of the cell cycle.

Interaction between the hydrophobic Bak BH3-binding groove and the BH3 domain of activator proteins is a key step in initiating Bak oligomerization and activation.


Sumoylation of α-synuclein decreases its rate of aggregation and its deleterious effects in vitro and in vivo.

p24 complexes act as cargo receptors for sorting GPI-anchored proteins into COPII vesicles.

The activity of siRNAs in gene silencing is regulated by protein complexes that sort cargo to lysosome-related organelles.

Two membrane curvature–sensing molecules with opposite chemistries are targeted to distinct vesicle classes through direct interaction with different lipid environments.

Tropomodulins, cytoplasmic γ-actin, and small ankyrin 1.5 mechanically stabilize the sarcoplasmic reticulum and maintain myofibril alignment in skeletal muscle fibers.

A PAR-1–mediated bias in microtubule organization in the Drosophila oocyte underlies posterior-directed mRNA transport.

Ipl1/Aurora-mediated phosphorylation of the CPC component Sli15/INCENP promotes microtubule dynamics by restricting CPC–spindle association.


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