On the cover
Uehara and Goshima follow the regrowth of depolymerized microtubules (green) in anaphase cells also stained for γ-tubulin (red) and DNA (blue). The Augmin complex is required for the de novo formation of anaphase microtubules and generation of a functional central spindle.
See page 259.
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The DNA damage–activated E3 ubiquitin ligase RAD18 promotes repair of interstrand DNA cross-links by ubiquitylating PCNA and recruiting FANCL to chromatin.
Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase
The augmin protein complex nucleates noncentrosomal microtubules during anaphase to promote completion of cell division.
Localization of the spindle and kinetochore proteins Astrin, SKAP, and LC8 is antagonized by Aurora B so that they target exclusively to bioriented kinetochores.
Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift
pRb is required to inhibit apoptosis in myoblasts and autophagy in myotubes but not for activation of the myogenic differentiation program.
Adhesive micropatterns show the effect of spatial confinement and actin network architecture on basal body positioning and primary cilium formation.
Low expression levels of Cdc20 result in chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome–microtubule attachment.
Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly
Cep120, a protein involved in maintenance of neural progenitor cells, is required for centriole duplication in cycling cells and for centriole amplification in tracheal epithelial cells.
Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier
Ion channel immobilization by ankyrin G is regulated by casein kinase 2 in immature hippocampal neurons.
Both Cdc2 and PKC-mediated phosphorylation of EBP50 alter accessibility of its first PDZ domain when its second PDZ domain is occupied to regulate microvilli formation on epithelial cells.
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
Hedgehog signaling through the ciliary membrane protein Smoothened dissociates the Gli transcription factors from their inhibitor, Suppressor of Fused.