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People & Ideas
Independently of their nucleation activity, γ-tubulin ring complex proteins localize along microtubules, limiting catastrophe events during interphase.
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity
The mechanism by which Raf-1 antagonizes Rok-α to promote migration and tumorigenesis is revealed.
Cripto-1 associates with Notch1 in the endoplasmic reticulum and Golgi to enhance Notch1 localization to lipid rafts and its maturation.
A distinct pathway for ligand-stimulated lateral trafficking of the hedgehog protein Smoothened into cilia is described.
Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes
A systems biology–based analysis shows that differentiating adipocytes look very different at the single-cell level and form distinct cellular subpopulations.
Multifunctional protein Rif1 accumulates at stalled replication forks to facilitate DNA repair during S phase.
The tug of war that ensues when a kinetochore binds microtubules from both spindle poles is resolved by Ase1/Prc1.
Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation
A screen identifies two more bouquet proteins required for meiotic telomere clustering: Bqt4 anchors the telomeres, whereas Bqt3 protects Bqt4 from degradation.
Cancer-expressed anti-apoptotic protein BCL-2 is stable, whereas MCL-1 undergoes proteasome-dependent degradation in response to chemotherapeutic agents.