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In Focus

Study on cell heterogeneity offers a surprising twist to adipocyte differentiation.

People & Ideas

A force behind both the science and politics of stem cell biology, Weissman now strives to translate his successes to the clinic.



Independently of their nucleation activity, γ-tubulin ring complex proteins localize along microtubules, limiting catastrophe events during interphase.

The mechanism by which Raf-1 antagonizes Rok-α to promote migration and tumorigenesis is revealed.

Cripto-1 associates with Notch1 in the endoplasmic reticulum and Golgi to enhance Notch1 localization to lipid rafts and its maturation.

Centriolar protein Ana3 is essential for basal body formation, not centriole duplication, as previously thought.

A distinct pathway for ligand-stimulated lateral trafficking of the hedgehog protein Smoothened into cilia is described.

A systems biology–based analysis shows that differentiating adipocytes look very different at the single-cell level and form distinct cellular subpopulations.


Multifunctional protein Rif1 accumulates at stalled replication forks to facilitate DNA repair during S phase.

The tug of war that ensues when a kinetochore binds microtubules from both spindle poles is resolved by Ase1/Prc1.

A screen identifies two more bouquet proteins required for meiotic telomere clustering: Bqt4 anchors the telomeres, whereas Bqt3 protects Bqt4 from degradation.

Cancer-expressed anti-apoptotic protein BCL-2 is stable, whereas MCL-1 undergoes proteasome-dependent degradation in response to chemotherapeutic agents.

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