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Cover Image
Cover Image
On the cover
In addition to nucleating microtubules (red), the γ-tubulin ring complex (green) binds along their length, acting as a stabilizing factor to control plus-end dynamics.
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In This Issue
In Focus
Not the average view of adipogenesis
Study on cell heterogeneity offers a surprising twist to adipocyte differentiation.
People & Ideas
Irving Weissman: Working for regenerative medicine
A force behind both the science and politics of stem cell biology, Weissman now strives to translate his successes to the clinic.
Review
Report
γ-Tubulin ring complexes regulate microtubule plus end dynamics
Independently of their nucleation activity, γ-tubulin ring complex proteins localize along microtubules, limiting catastrophe events during interphase.
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity
The mechanism by which Raf-1 antagonizes Rok-α to promote migration and tumorigenesis is revealed.
Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1
Cripto-1 associates with Notch1 in the endoplasmic reticulum and Golgi to enhance Notch1 localization to lipid rafts and its maturation.
Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies
Centriolar protein Ana3 is essential for basal body formation, not centriole duplication, as previously thought.
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
A distinct pathway for ligand-stimulated lateral trafficking of the hedgehog protein Smoothened into cilia is described.
Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes
A systems biology–based analysis shows that differentiating adipocytes look very different at the single-cell level and form distinct cellular subpopulations.
Article
Mammalian Rif1 contributes to replication stress survival and homology-directed repair
Multifunctional protein Rif1 accumulates at stalled replication forks to facilitate DNA repair during S phase.
Ase1/Prc1-dependent spindle elongation corrects merotely during anaphase in fission yeast
The tug of war that ensues when a kinetochore binds microtubules from both spindle poles is resolved by Ase1/Prc1.
Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation
A screen identifies two more bouquet proteins required for meiotic telomere clustering: Bqt4 anchors the telomeres, whereas Bqt3 protects Bqt4 from degradation.
MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts
Cancer-expressed anti-apoptotic protein BCL-2 is stable, whereas MCL-1 undergoes proteasome-dependent degradation in response to chemotherapeutic agents.
