On the cover
In mouse whiskers, as well as other regions of the skin, Merkel cells (red) transmit mechanical stimuli to sensory neurons (green). Van Keymeulen et al. demonstrate that Merkel cells develop from epidermal, rather than neural crest progenitors.
See page 91.
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People & Ideas
DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos
Deletion of S phase disrupts mitotic timing in maternally regulated cycles, but it doesn't alter the cell cycle once zygotic transcription has begun.
Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis
Increased amounts of single-stranded DNA accumulate at replication forks when Tim–Tipin isn't around, activating an ATR-mediated DNA damage response necessary for DNA replication to proceed.
It's the kinetochores, not the DNA, that initiate spindle assembly.
A combination of experimentation and modeling reveal that multiple myosin VI molecules coordinately transport cargo over the actin filament network.
Glyburide, a sulfonylurea drug commonly used to treat type 2 diabetes, shuts down IL-1β secretion by preventing Cyropyrin activation.
The ubiquitin–proteosome and autophagy pathways work together to regulate synaptic growth and plasticity in response to environmental conditions.
Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model
Chlamydomonas reinhardtii IFT particle trains, important for flagella maintenance and assembly, are observed to decrease in size as a function of cilia length.
Lineage-tracing experiments show that the origin of specialized mechanosensory Merkel cells in the skin is epidermal progenitors, not the neural crest.
Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton
Neuromuscular junctions crippled by a disrupted microtubule cytoskeleton are rescued by stress-induced activation of MAPK-JNK-Fos signaling.
Rho promotes actomyosin contractility during epithelial cell remodeling, but Cdc42 keeps the epithelium in shape by limiting RhoA activity.
Ultrastructural study of Chlamydomonas cilia shows that anterograde IFT particles form trains that are long and narrow, while retrograde IFT form short, compact particle trains.