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    On the cover
    In mouse whiskers, as well as other regions of the skin, Merkel cells (red) transmit mechanical stimuli to sensory neurons (green). Van Keymeulen et al. demonstrate that Merkel cells develop from epidermal, rather than neural crest progenitors.
    See page 91.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study suggests that asynchronous molecular motors can integrate their actions.

People & Ideas

Conboy has found her niche in chasing down what ails aged, decrepit muscle stem cells.


Deletion of S phase disrupts mitotic timing in maternally regulated cycles, but it doesn't alter the cell cycle once zygotic transcription has begun.

Increased amounts of single-stranded DNA accumulate at replication forks when Tim–Tipin isn't around, activating an ATR-mediated DNA damage response necessary for DNA replication to proceed.

MISE is identified as a component of the Integrator complex required for DNA repair.

SPN2 represses katanin translation to prevent mitotic defects (independently of ubiquitin-mediated katanin degradation).

It's the kinetochores, not the DNA, that initiate spindle assembly.

A combination of experimentation and modeling reveal that multiple myosin VI molecules coordinately transport cargo over the actin filament network.

Glyburide, a sulfonylurea drug commonly used to treat type 2 diabetes, shuts down IL-1β secretion by preventing Cyropyrin activation.

The ubiquitin–proteosome and autophagy pathways work together to regulate synaptic growth and plasticity in response to environmental conditions.

Chlamydomonas reinhardtii IFT particle trains, important for flagella maintenance and assembly, are observed to decrease in size as a function of cilia length.

Lineage-tracing experiments show that the origin of specialized mechanosensory Merkel cells in the skin is epidermal progenitors, not the neural crest.


Neuromuscular junctions crippled by a disrupted microtubule cytoskeleton are rescued by stress-induced activation of MAPK-JNK-Fos signaling.

Rho promotes actomyosin contractility during epithelial cell remodeling, but Cdc42 keeps the epithelium in shape by limiting RhoA activity.

Ultrastructural study of Chlamydomonas cilia shows that anterograde IFT particles form trains that are long and narrow, while retrograde IFT form short, compact particle trains.

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