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Apratoxin chaperones EGFR to its destruction

Ben Short
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BDNF sends mixed signals

Ben Short
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Decorin has Met a new receptor

Ben Short
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In Focus

Lipid rafts inflate at the trans-Golgi

Ben Short

A new method to characterize the lipid content of vesicles suggests how cells sort secretory cargo.

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People & Ideas

David Sherwood: Invasive procedures

Ben Short

Sherwood uses a unique in vivo model to study how cells invade through extracellular barriers.

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Editorial

A challenge to Goliath

Mike Rossner
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Review

Revisiting the role of heterochromatin protein 1 in DNA repair

Alexander R. Ball, Jr.,Kyoko Yokomori
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Report

Heterochromatin protein 1 is recruited to various types of DNA damage

Martijn S. Luijsterburg,Christoffel Dinant,Hannes Lans,Jan Stap,Elzbieta Wiernasz,Saskia Lagerwerf,Daniël O. Warmerdam,Michael Lindh,Maartje C. Brink,Jurek W. Dobrucki,Jacob A. Aten,Maria I. Fousteri,Gert Jansen,Nico P. Dantuma,Wim Vermeulen,Leon H.F. Mullenders,Adriaan B. Houtsmuller,Pernette J. Verschure,Roel van Driel
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Article

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation

Sophie Badie,Chunyan Liao,Maria Thanasoula,Paul Barber,Mark A. Hill,Madalena Tarsounas
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Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network

Robin W. Klemm,Christer S. Ejsing,Michal A. Surma,Hermann-Josef Kaiser,Mathias J. Gerl,Julio L. Sampaio,Quentin de Robillard,Charles Ferguson,Tomasz J. Proszynski,Andrej Shevchenko,Kai Simons
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The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster

Akos Szakmary,Mary Reedy,Hongying Qi,Haifan Lin
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Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy

Shensi Shen,Pengtao Zhang,Martin A. Lovchik,Ying Li,Liuya Tang,Zhimin Chen,Rong Zeng,Dawei Ma,Junying Yuan,Qiang Yu
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TIP47 functions in the biogenesis of lipid droplets

Anna V. Bulankina,Anke Deggerich,Dirk Wenzel,Kudzai Mutenda,Julia G. Wittmann,Markus G. Rudolph,Koert N.J. Burger,Stefan Höning
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VE-PTP controls blood vessel development by balancing Tie-2 activity

Mark Winderlich,Linda Keller,Giuseppe Cagna,Andre Broermann,Olena Kamenyeva,Friedemann Kiefer,Urban Deutsch,Astrid F. Nottebaum,Dietmar Vestweber
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The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

Salit Tzaban,Ramiro H. Massol,Elizabeth Yen,Wendy Hamman,Scott R. Frank,Lynne A. Lapierre,Steen H. Hansen,James R. Goldenring,Richard S. Blumberg,Wayne I. Lencer
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Regulation of glutamate receptor subunit availability by microRNAs

Julie Karr,Vasia Vagin,Kaiyun Chen,Subhashree Ganesan,Oxana Olenkina,Vladimir Gvozdev,David E. Featherstone
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Integrin-mediated axoglial interactions initiate myelination in the central nervous system

Joana Câmara,Zhen Wang,Cristina Nunes-Fonseca,Hana C. Friedman,Matthew Grove,Diane L. Sherman,Noboru H. Komiyama,Seth G. Grant,Peter J. Brophy,Alan Peterson,Charles ffrench-Constant
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Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction

Carlos Merino,Jay Penney,Miranda González,Kazuya Tsurudome,Myriam Moujahidine,Michael B. O'Connor,Esther M. Verheyen,Pejmun Haghighi
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Pro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses

Feng Yang,Hyun-Soo Je,Yuanyuan Ji,Guhan Nagappan,Barbara Hempstead,Bai Lu
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Decorin is a novel antagonistic ligand of the Met receptor

Silvia Goldoni,Ashley Humphries,Alexander Nyström,Sampurna Sattar,Rick T. Owens,David J. McQuillan,Keith Ireton,Renato V. Iozzo
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