Reviews on Stem Cells 2018
We are pleased to present this collection of reviews on stem cells, the topic of the 2018 ASCB Doorstep Meeting. Learn about stem cells during development beginning with the changes in DNA methylation, chromatin accessibility, and topological architecture that occur during the reprogramming to totipotency in the early embryo, as well as the epigenetic and epitranscriptomic mechanisms that regulate the lineage specification of neural progenitor cells in the developing brain. Read about the mechanisms of asymmetric stem cell division that balance stem cell self-renewal and differentiation. Finally, learn about how a decline in stem cell renewal and function with aging affects tissue homeostasis and regeneration.