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DNA Replication and Genome Instability 2019

The maintenance of genome stability throughout cell division is essential for cell survival, tissue homeostasis, and normal development. Disruptions in genome stability and nuclear integrity are linked to diseases in all organ systems. Understanding the fundamental mechanisms of DNA replication, recombination, and repair at the cellular, molecular, and structural levels is critical to tackle their contributions to disease and develop targeted therapies. In this special collection of recently published JCB articles, JCB Editorial Board member Agata Smogorzewska and Senior Scientific Editor Melina Casadio explore exciting advances in the biology of vital processes that assure genome stability from replication through mitosis. Articles were selected based on scope and requests for full-text and PDF versions from readers. We hope you enjoy this collection and welcome your feedback on Twitter and Facebook.

Micrograph © 2018 Manil-Ségalen et al.

KEYWORDS:

Replication fork, Replication stress, DNA replication, Recombination, Genome instability, DNA damage, DNA damage response, DNA repair, Chromatin, Replication-Transcription Conflict

Special Collection Image
Article
Panagiotis Mistriotis; Emily O. Wisniewski; Kaustav Bera; Jeremy Keys; Yizeng Li; Soontorn Tuntithavornwat; Robert A. Law; Nicolas A. Perez-Gonzalez; Eda Erdogmus; Yuqi Zhang; Runchen Zhao; Sean X. Sun; Petr Kalab; Jan Lammerding; Konstantinos Konstantopoulos
DOI: 10.1083/jcb.201902057
Article
Alison E. Patteson; Amir Vahabikashi; Katarzyna Pogoda; Stephen A. Adam; Kalpana Mandal; Mark Kittisopikul; Suganya Sivagurunathan; Anne Goldman; Robert D. Goldman; Paul A. Janmey
DOI: 10.1083/jcb.201902046
Article
Yuntao Xia; Charlotte R. Pfeifer; Kuangzheng Zhu; Jerome Irianto; Dazhen Liu; Kalia Pannell; Emily J. Chen; Lawrence J. Dooling; Michael P. Tobin; Mai Wang; Irena L. Ivanovska; Lucas R. Smith; Roger A. Greenberg; Dennis E. Discher
DOI: 10.1083/jcb.201811100
Spotlight
J. Julian Blow
DOI: 10.1083/jcb.201905181
Report
Charles T. Halfmann; Rhiannon M. Sears; Aditya Katiyar; Brook W. Busselman; London K. Aman; Qiao Zhang; Christopher S. O’Bryan; Thomas E. Angelini; Tanmay P. Lele; Kyle J. Roux
DOI: 10.1083/jcb.201901116
Article
Ryosuke Nagashima; Kayo Hibino; S.S. Ashwin; Michael Babokhov; Shin Fujishiro; Ryosuke Imai; Tadasu Nozaki; Sachiko Tamura; Tomomi Tani; Hiroshi Kimura; Michael Shribak; Masato T. Kanemaki; Masaki Sasai; Kazuhiro Maeshima
DOI: 10.1083/jcb.201811090
Spotlight
Sharon Cantor
DOI: 10.1083/jcb.201812142
Report
Andrea K. Byrum; Denisse Carvajal-Maldonado; Miranda C. Mudge; David Valle-Garcia; Mona C. Majid; Romil Patel; Mathew E. Sowa; Steven P. Gygi; J. Wade Harper; Yang Shi; Alessandro Vindigni; Nima Mosammaparast
DOI: 10.1083/jcb.201803003
Report
Yuntao Xia; Irena L. Ivanovska; Kuangzheng Zhu; Lucas Smith; Jerome Irianto; Charlotte R. Pfeifer; Cory M. Alvey; Jiazheng Ji; Dazhen Liu; Sangkyun Cho; Rachel R. Bennett; Andrea J. Liu; Roger A. Greenberg; Dennis E. Discher
DOI: 10.1083/jcb.201711161
Correction
Wanqing Xiang; M. Julia Roberti; Jean-Karim Hériché; Sébastien Huet; Stephanie Alexander; Jan Ellenberg
DOI: 10.1083/JCB.20170907408082018c
Article
Marion Manil-Ségalen; Małgorzata Łuksza; Joanne Kanaan; Véronique Marthiens; Simon I.R. Lane; Keith T. Jones; Marie-Emilie Terret; Renata Basto; Marie-Hélène Verlhac
DOI: 10.1083/jcb.201806072
Report
Vincent Amarh; Martin A. White; David R.F. Leach
DOI: 10.1083/jcb.201803020
Spotlight
Hilary A. Coller
DOI: 10.1083/jcb.201803037
Article
Thomas D. Carroll; Ian P. Newton; Yu Chen; J. Julian Blow; Inke Näthke
DOI: 10.1083/jcb.201708023
Correction
Sunetra Roy; Jessica W. Luzwick; Katharina Schlacher
DOI: 10.1083/JCB.20170912103212018c
Article
Wanqing Xiang; M. Julia Roberti; Jean-Karim Hériché; Sébastien Huet; Stephanie Alexander; Jan Ellenberg
DOI: 10.1083/jcb.201709074
Spotlight
Dana Branzei; Michele Giannattasio
DOI: 10.1083/jcb.201802083
Tools
Sunetra Roy; Jessica W. Luzwick; Katharina Schlacher
DOI: 10.1083/jcb.201709121
Spotlight
Rachel J. O’Neill; Michael J. O’Neill
DOI: 10.1083/jcb.201712173
Article
Emily J. Platt; Leslie Smith; Mathew J. Thayer
DOI: 10.1083/jcb.201707082
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