Cell-free plasma-derived serum (PDS) is deficient in the platelet-derived growth factor and will not support the growth of 3T3 cells, fibroblasts, or smooth muscle cells. However, when PDS-containing medium is preincubated with endothelial cells, the medium becomes modified so that it will support growth. The activity produced by the endothelial cells results from a polypeptide of 10,000 to 30,000 daltons which has several features that differ from those of the platelet-derived growth factor, including heat instability and lack of adsorption to CM Sephadex.
Article| May 01 1980
An endothelial cell-derived growth factor.
S M Schwartz
Online Issn: 1540-8140
Print Issn: 0021-9525
J Cell Biol (1980) 85 (2): 467–472.
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C Gajdusek, P DiCorleto, R Ross, S M Schwartz; An endothelial cell-derived growth factor.. J Cell Biol 1 May 1980; 85 (2): 467–472. doi: https://doi.org/10.1083/jcb.85.2.467
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