The morphology of the tight junction of rat thyroid epithelium was examined in freeze-fractured material fixed in glutaraldehyde and briefly glycerinated. In normal thyroids the overall appearance of this junctional specialization resembled that of other cell types in many respects. Short-term changes in thyroid activity and hypophysectomy for 3 wk did not obviously affect the appearance of tight junctions. Feeding of the goitrogen, thiouracil, which stimulates secretion of thyroid-stimulating hormone, resulted in the appearance of some very narrow and some very wide, tight junctions or sometimes junctions with both wide and narrow regions within the same cell.
Article| September 01 1975
Changes in tight junctions of thyroid epithelium with changes in thyroid activity.
L W Tice
S H Wollman
R C Carter
Online ISSN: 1540-8140
Print ISSN: 0021-9525
J Cell Biol (1975) 66 (3): 657–663.
L W Tice, S H Wollman, R C Carter; Changes in tight junctions of thyroid epithelium with changes in thyroid activity.. J Cell Biol 1 September 1975; 66 (3): 657–663. doi: https://doi.org/10.1083/jcb.66.3.657
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