The effects of lanthanum ions (La+++) on the locomotion and adhesion of g lial cells and elongating nerve axons are reported. La+++ increases adhesion of both glia and of nerve growth cones to a plastic substratum. La+++ also markedly reduces glia locomotion, but it does not inhibit nerve elongation. Electron-opaque deposits are seen on the cell surface and within cytoplasmic vesicles of glia and nerves cultured in a La+++-containing medium. Possible modes of action for La+++ are discussed, particularly the possibilities that Ca++ fluxes or Ca++ involvement in adhesion are altered by La+++. The results are consistent with the hypothesis that cell migration and nerve axon elongation differ in mechanism, with respect to both adhesive interactions and the activity of microfilament systems.
MIGRATORY CELL LOCOMOTION VERSUS NERVE AXON ELONGATION : Differences Based on the Effects of Lanthanum Ion
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Paul C. Letourneau, Norman K. Wessells; MIGRATORY CELL LOCOMOTION VERSUS NERVE AXON ELONGATION : Differences Based on the Effects of Lanthanum Ion . J Cell Biol 1 April 1974; 61 (1): 56–69. doi: https://doi.org/10.1083/jcb.61.1.56
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