The effects of lanthanum ions (La+++) on the locomotion and adhesion of g lial cells and elongating nerve axons are reported. La+++ increases adhesion of both glia and of nerve growth cones to a plastic substratum. La+++ also markedly reduces glia locomotion, but it does not inhibit nerve elongation. Electron-opaque deposits are seen on the cell surface and within cytoplasmic vesicles of glia and nerves cultured in a La+++-containing medium. Possible modes of action for La+++ are discussed, particularly the possibilities that Ca++ fluxes or Ca++ involvement in adhesion are altered by La+++. The results are consistent with the hypothesis that cell migration and nerve axon elongation differ in mechanism, with respect to both adhesive interactions and the activity of microfilament systems.
Article|
April 01 1974
MIGRATORY CELL LOCOMOTION VERSUS NERVE AXON ELONGATION : Differences Based on the Effects of Lanthanum Ion
Paul C. Letourneau
,
Paul C. Letourneau
From the Department of Biological Sciences, Stanford University, Stanford, California 94305
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Norman K. Wessells
Norman K. Wessells
From the Department of Biological Sciences, Stanford University, Stanford, California 94305
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Paul C. Letourneau
From the Department of Biological Sciences, Stanford University, Stanford, California 94305
Norman K. Wessells
From the Department of Biological Sciences, Stanford University, Stanford, California 94305
Received:
July 30 1973
Revision Received:
December 03 1973
Online Issn: 1540-8140
Print Issn: 0021-9525
Copyright © 1974 by The Rockefeller University Press
1974
J Cell Biol (1974) 61 (1): 56–69.
Article history
Received:
July 30 1973
Revision Received:
December 03 1973
Citation
Paul C. Letourneau, Norman K. Wessells; MIGRATORY CELL LOCOMOTION VERSUS NERVE AXON ELONGATION : Differences Based on the Effects of Lanthanum Ion . J Cell Biol 1 April 1974; 61 (1): 56–69. doi: https://doi.org/10.1083/jcb.61.1.56
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