Beta granules isolated from rat islets of Langerhans and subjected only to phosphotungstic acid had, in negatively stained images, a 50-A periodicity. This periodicity was also observed in thin-section profiles of beta granules in intact cells. In shadowed preparations, the granules were spherical in shape and had irregular edges and surface structure. The presence of such a periodicity in the beta granule indicates that its matrix may be composed of a crystalline material.
ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS : II. Ultrastructure of the Beta Granule
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Marie H. Greider, S. L. Howell, P. E. Lacy; ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS : II. Ultrastructure of the Beta Granule . J Cell Biol 1 April 1969; 41 (1): 162–166. doi: https://doi.org/10.1083/jcb.41.1.162
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