Paradigm lost: milton connects kinesin heavy chain to miro on mitochondria

The kinesin motor typically binds to cargo through its light chains. In this issue Glater et al. (p. 545) demonstrate a new type of linkage through the adapter protein, milton, and the mitochondrial membrane GTPase, miro. This is an important result because it represents a new mechanism of cargo binding and because miro's ability to bind GTP and calcium suggests that it is involved in the regulation of mitochondrial transport.