Regulation of WASP/WAVE proteins making a long story short

Bompard , Guillaume; Caron , Emmanuelle

doi:10.1083/jcb.200403127

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Review| September 27 2004

Regulation of WASP/WAVE proteins : making a long story short

Guillaume Bompard,

Guillaume Bompard

1School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, England, UK

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Emmanuelle Caron

2Centre for Molecular Microbiology and Infection and Department of Biological Sciences, Imperial College London, London SW7 2AZ, England, UK

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Author and Article Information

Guillaume Bompard

1School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, England, UK

Emmanuelle Caron

2Centre for Molecular Microbiology and Infection and Department of Biological Sciences, Imperial College London, London SW7 2AZ, England, UK

Address correspondence to Guillaume Bompard, School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, England, UK. Tel.: 44-121-414-2508. Fax: 44-121-414-5925. email: [email protected]

Abbreviations used in this paper: Abi, Abl interactor; GBD, GTPase binding domain; Nap1, Nck-associated protein; PIR121, p53 inducible messenger RNA; SCAR, suppressor of cAMP receptor; WASP, WAVE, WASP family verprolin homologous; Wiskott-Aldrich syndrome protein; WHD, WASP homology domain.

Received: March 22 2004

Accepted: August 10 2004

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2004

J Cell Biol (2004) 166 (7): 957–962.

https://doi.org/10.1083/jcb.200403127

Despite their homology, the regulation of WASP and WAVE, activators of Arp2/3-dependent actin polymerization, has always been thought to be different. Several recent studies have revealed new aspects of their regulation, highlighting its complexity and the crucial role of post-translational modifications. New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models.

The Rockefeller University Press

2004

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