In this issue, McDonald et al. describe the itinerary of the incoming human immunodeficiency virus (HIV)*
*
during its travels to the host nucleus. They show that subviral particles tagged with the green fluorescent protein (GFP) are propelled along microtubules (MTs) by minus-end–directed and presumably plus-end–directed MT motors. The tracked particles correspond to functional units, since they no longer include a viral envelope, but do include viral matrix protein, Vpr, capsid protein, and reverse transcription activity. Abbreviations used in this paper: GFP, green fluorescent protein; HIV, human immunodeficiency virus; MT, microtubules; RTC, reverse transcription complex.
The Rockefeller University Press
2002
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