When salvador is lost (black patches, right image), replication (red) continues.
Hariharan/Elsevier
salvador is one of many genes that Hariharan isolated in a screen for cell growth mutants. Mitotic recombination in fly eyes rendered possible mutations homozygous. Then Hariharan's group (four postdocs working for two years) looked for mutant patches that grew larger than the corresponding wild-type patch. “One of the lessons is that there are many pathways that we know nothing about,” says Hariharan. “That's why we did a phenotype-based screen, because that assumes nothing.”
salvador appears to be part of a new pathway, but it can be tied to certain known cellular events. In late larval stages it induces cell cycle exit by down-regulating cyclin E, with...
