How intracellular cytoskeletal and signaling proteins connect and communicate with the extracellular matrix (ECM) is a fundamental question in cell biology. Recent biochemical, cell biological, and genetic studies have revealed important roles of cytoplasmic integrin-linked kinase (ILK) and its interactive proteins in these processes. Cell adhesion to ECM is an important process that controls cell shape change, migration, proliferation, survival, and differentiation. Upon adhesion to ECM, integrins and a selective group of cytoskeletal and signaling proteins are recruited to cell matrix contact sites where they link the actin cytoskeleton to the ECM and mediate signal transduction between the intracellular and extracellular compartments. In this review, we discuss the molecular activities and cellular functions of ILK, a protein that is emerging as a key component of the cell–ECM adhesion structures.
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12 November 2001
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November 05 2001
Integrin-linked kinase (ILK) and its interactors : a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
J Cell Biol (2001) 155 (4): 505–510.
Article history
Received:
August 16 2001
Revision Received:
October 01 2001
Accepted:
October 02 2001
