Heparin-binding growth factor-2 (HBGF-2; also known as basic fibroblast growth factor) is mitogenic for most anchorage-dependent cells. It is shown here that HBGF-2 stimulates cell-substratum adhesion and neurite extension in the sympathetic nerve cell line PC12. When HBGF-2 is adsorbed to artificial extracellular matrices consisting of heparin or chondroitin sulfate, it causes the formation of cellular aggregates or circles of cells, respectively. HBGF-2 is also a nerve cell survival molecule, for it potentiates the survival of primary cultures of embryonic chick ciliary ganglion cells but not of embryonic neural retina cells. Finally, a series of synthetic peptides from the HBGF-2 sequence is described that selectively alter the biological effects of HBGF-2. The amphiphilic nature of one of these peptides is discussed with respect to its ability to stimulate cell adhesion.
Article| March 01 1987
Multiple influences of a heparin-binding growth factor on neuronal development.
Online Issn: 1540-8140
Print Issn: 0021-9525
J Cell Biol (1987) 104 (3): 635–643.
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D Schubert, N Ling, A Baird; Multiple influences of a heparin-binding growth factor on neuronal development.. J Cell Biol 1 March 1987; 104 (3): 635–643. doi: https://doi.org/10.1083/jcb.104.3.635
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