Demineralized sections of fluorinated bones and teeth have been studied by autoradiography following in vitro uptake of Ca45 or S35O4.

The portions of tissue which do not become mineralized (cartilage, prebone, predentine, and precementum) show an increased Ca45 uptake apparently related to an increase in chondroitin sulfate content in fluorosis.

The tissues from the fluoride-fed animals show an increase of in vitro uptake of sulfur in the tissues which become mineralized (bone, dentine, cementum).

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