Overexpressed p107 (open boxes) makes Skp2 unstable.

Pocket proteins find multiple routes to stop cell proliferation, according to results on page 55, from Rodier et al.The well-known antiproliferative route taken by pocket proteins, including pRb and p107, is through interaction with E2F. When bound to pRb, E2F cannot initiate the transcription of cell cycle progression genes, and cells thus linger in G1.