Myo4p concentrates labeled mRNA in a yeast bud (left), but the cargo remains dispersed if the cell lacks the myosin (right).
When a yeast cell sprouts a bud, two myosin proteins help furnish the new structure with necessities. Myo2p trucks in organelles and vesicles essential for growth, whereas Myo4p hauls mRNA that helps the bud differentiate from the mother cell. Running on tracks of actin, the proteins seem to keep their cargos moving continuously. That presents a mystery, however, because evidence suggests that the individual myosins are nonprocessive—they let go of the tracks after every power stroke, instead of remaining attached and sliding along.
To resolve that apparent contradiction, Dunn...
The Rockefeller University Press
2007
The Rockefeller University Press
2007
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