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Volume 50, Issue 3
1 September 1971
Journal of Cell Biology Cover Image for Volume 50, Issue 3
Article| September 01 1971

DEXTRANS AND GLYCOGENS AS PARTICULATE TRACERS FOR STUDYING CAPILLARY PERMEABILITY

Nicolae Simionescu,
Nicolae Simionescu
From The Rockefeller University, New York 10021.
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George E. Palade
George E. Palade
From The Rockefeller University, New York 10021.
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Author and Article Information
Nicolae Simionescu
From The Rockefeller University, New York 10021.
George E. Palade
From The Rockefeller University, New York 10021.
Dr. Simionescu's permanent address is Institute of Endocrinology, Bucharest, Romania
Received: November 20 1970
Revision Received: January 04 1971
Online ISSN: 1540-8140
Print ISSN: 0021-9525
Copyright © 1971 by The Rockefeller University Press
1971
J Cell Biol (1971) 50 (3): 616–624.
https://doi.org/10.1083/jcb.50.3.616
Article history
Received:
November 20 1970
Revision Received:
January 04 1971

Commercially available glycogens and dextrans can be used as biological particulate tracers in work on capillary permeability. These polysaccharides are well tolerated in intravenous injection and induce no vascular leakage when applied topically (cremaster test) in mice and in Wistar-Furth rats. The particles stain adequately with lead after aldehyde-OsO4 fixation in phosphate buffer and provide a relatively wide set of probes (∼45 A-300 A) for work on the large and small pore systems.

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Copyright © 1971 by The Rockefeller University Press
1971
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