THE TURNOVER OF NUCLEAR DNA-LIKE RNA IN HELA CELLS

Soeiro , R.; Vaughan , M. H.; Warner , J. R.; Darnell , J. E.

doi:10.1083/jcb.39.1.112

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Article| October 01 1968

THE TURNOVER OF NUCLEAR DNA-LIKE RNA IN HELA CELLS

R. Soeiro,

R. Soeiro

From the Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 10461.

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M. H. Vaughan,

M. H. Vaughan

From the Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 10461.

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J. R. Warner,

J. R. Warner

From the Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 10461.

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J. E. Darnell, Jr.

From the Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 10461.

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Author and Article Information

R. Soeiro

From the Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 10461.

M. H. Vaughan

From the Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 10461.

J. R. Warner

From the Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 10461.

J. E. Darnell, Jr.

From the Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 10461.

Dr. Vaughan's present address is the Department of Biochemistry and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213

Received: April 17 1968

Revision Received: May 27 1968

Online ISSN: 1540-8140

Print ISSN: 0021-9525

1968

J Cell Biol (1968) 39 (1): 112–118.

https://doi.org/10.1083/jcb.39.1.112

The subcellular distribution of various types of RNA in HeLa cells is described. In addition, the relative rate of synthesis of the major classes of nuclear RNA has been determined. From these experiments it can be deduced that the heterogeneous nuclear RNA fraction is rapidly synthesized and degraded within the cell nucleus.

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