MUCOPOLYSACCHARIDES PRODUCED IN TISSUE CULTURE

Grossfeld , Henry; Meyer , Karl; Godman , Gabriel; Linker , Alfred

doi:10.1083/jcb.3.3.391

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Article| May 25 1957

MUCOPOLYSACCHARIDES PRODUCED IN TISSUE CULTURE

Henry Grossfeld,

Henry Grossfeld

From the Department of Medicine and the Histochemical Research Laboratory, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York

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Karl Meyer,

Karl Meyer

From the Department of Medicine and the Histochemical Research Laboratory, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York

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Gabriel Godman,

Gabriel Godman

From the Department of Medicine and the Histochemical Research Laboratory, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York

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Alfred Linker

From the Department of Medicine and the Histochemical Research Laboratory, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York

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Author and Article Information

Henry Grossfeld

From the Department of Medicine and the Histochemical Research Laboratory, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York

Karl Meyer

From the Department of Medicine and the Histochemical Research Laboratory, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York

Gabriel Godman

From the Department of Medicine and the Histochemical Research Laboratory, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York

Alfred Linker

From the Department of Medicine and the Histochemical Research Laboratory, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York

Received: December 04 1956

Copyright, 1957, by The Rockefeller Institute for Medical Research

1957

J Biophys and Biochem Cytol (1957) 3 (3): 391–396.

https://doi.org/10.1083/jcb.3.3.391

1. A method of mass tissue culture has been devised by which, in a relatively short period of time, samples large enough for chemical isolation of mucopolysaccharides can be obtained.

2. Chemical isolation of acid mucopolysaccharides from mass cultures of human fetal skin, human fetal bone, bovine fetal skin, and rat subcutaneous tissue has been carried out. It has been found that the fibroblasts of each of these tissues produce in tissue culture more than one mucopolysaccharide, namely, hyaluronic acid, and a chondroitin sulfate.

3. The chondroitin sulfate produced by fibroblasts of the above tissues in tissue culture was not fully sulfated. The possible significance of this finding is discussed.

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Copyright, 1957, by The Rockefeller Institute for Medical Research

1957

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