In this issue, Thaller et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202004222) explore how the ESCRT protein Chm7 is recruited to sites of defective nuclear pore assembly. They show that a lipid, phosphatidic acid, is enriched at pathological nuclear envelope herniations, where it promotes Chm7 recruitment for membrane surveillance and repair.
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Spotlight| February 11 2021
Nuclear envelope lipids request border surveillance
Max Perutz Labs, University of Vienna and Medical University of Vienna, Vienna Biocenter Campus, Vienna, Austria
Online Issn: 1540-8140
Print Issn: 0021-9525
© 2021 Köhler
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
J Cell Biol (2021) 220 (3): e202101164.
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Alwin Köhler; Nuclear envelope lipids request border surveillance. J Cell Biol 1 March 2021; 220 (3): e202101164. doi: https://doi.org/10.1083/jcb.202101164
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