Breast cancer cells (green) are more likely to metastasize to the lung if MSCs are around (right) to enhance their invasive ability.
KARNOUB/MACMILLAN
A growing tumor is considered by its surrounding normal tissue to be a bit like a wound. As also occurs during the wound response, tumors recruit mesenchymal stem cells (MSCs)—which are meant to help with repair—from the bone marrow. Karnoub et al. hypothesized that these MSCs, rather than being helpful, may instead advance disease. To investigate this idea, they injected human breast cancer cells, either alone or along with human MSCs, into mice and then looked for...
The Rockefeller University Press
2007
The Rockefeller University Press
2007
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