The ER in budding yeast (colored lines) has less cortex (red) and more cytoplasmic (yellow) association when Scs2 is missing (bottom). Nuclear-associated ER (blue) appears normal.
The positioning of particular organelles can often be important for cell function. How a cell senses organelle positioning, however, is unknown. The budding yeast is a useful model organism for getting to the bottom of this question, as its organelles move into the bud in a highly ordered manner. The ER, for example, travels along actin cables into the bud, and then attaches to the bud tip and spreads around the cortex.
Sites of contact between the ER and the plasma membrane are enriched in an ER transmembrane protein called Scs2. Loewen et al. now show...
The Rockefeller University Press
2007
The Rockefeller University Press
2007
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