A long telomere (blue, left) is replicated later in S phase than a shortened version of the same telomere (right).

BIANCHI/ELSEVIER

Like first-class airline passengers, short telomeres get preferential treatment. They cut to the front of the line during DNA replication, according to Alessandro Bianchi and David Shore (University of Geneva, Switzerland).

The shortening of telomeres with each cell division is counteracted by telomerase, which extends these repetitive sequences that cap the ends of linear chromosomes. The squeaky telomere gets the grease, however, as shorter ends seem to recruit or activate more telomerase.

Bianchi and Shore set out to examine the basis of this inequality by comparing individual short and long telomeres. “We expected to see a quantitative difference in the binding of telomerase or Cdc13, which activates it,” says Bianchi. “But instead we noticed a shift in the replication timing.” Shorter telomeres were replicated...

The Rockefeller University Press
2007
The Rockefeller University Press
2007
You do not currently have access to this content.