Clones lacking Notch signaling (green) maintain E-cadherin (red) junctions (white arrow) when normal regions have dismantled them (yellow arrow).
Developmental programs generally require plenty of changes in cell shape. In the developing fly oocyte, a set of cells on the posterior end acquire a columnar shape, whereas anterior cells flatten. Notch has been implicated in several aspects of oogenesis in flies. To better dissect its role, Grammont analyzed developing oocytes with somatic clones mutant for Notch signaling.
The clones revealed that Notch activity is necessary for the anterior cells to take on their new flattened shapes at the proper time. Mutant clones were delayed in...
The Rockefeller University Press
2007
The Rockefeller University Press
2007
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