Late endosomes (red) scatter to the cell periphery when the p14 adaptor is missing.
Mice lacking p14 died as embryos. Fibroblasts from the embryos had normal early endosomes but, compared with wild-type cells, twice as many of their late endosomes and lysosomes were located far from the nucleus, and degradation of internalized EGF receptor was half as efficient.
Epidermal-specific deletion of p14 resulted in mice that were born alive but died soon after from dehydryation. EGF receptors, normally found only in basal cell layers, were not degraded properly and were therefore expressed even in suprabasal cell layers....
The Rockefeller University Press
2006
The Rockefeller University Press
2006
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