eIF4E (green) exports transcripts with a particular stem loop structure (red), but PML (blue) interferes with their interaction.
The moonlighting is nothing new for this translation initiation factor—boosting eIF4E was known to increase the nuclear export of transcripts for cyclin D1 and ornithine decarboxylase. But the authors now find that eIF4E has many nuclear targets, most of which encode proteins that promote survival and cell division. High levels of eIF4E increased the export of these messages and, consequently, levels of their proteins.
In the cytoplasm, eIF4E binds to the m7G that...
The Rockefeller University Press
2006
The Rockefeller University Press
2006
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