Integrins for mitosis

For many cell types, division does not occur unless the cells are stuck to a matrix. The blockade to division was first linked to integrins when it was discovered that cells do not enter S phase in response to growth factors unless integrins are engaged.

In the new report, the authors identify an inactive integrin β mutant that nevertheless supports entry into S phase. Once in mitosis, however, cells adhering via this mutant are unable to build a proper microtubule array. Although some cells had no spindle, others were multipolar. Most never completed cytokinesis, probably due to a defective...